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Review
. 2021 Mar 25:9:652214.
doi: 10.3389/fbioe.2021.652214. eCollection 2021.

Regenerative Medicine of Epithelia: Lessons From the Past and Future Goals

Eleonora Maurizi  1 , Davide Adamo  2 , Federica Maria Magrelli  1 , Giulia Galaverni  2 , Eustachio Attico  2 , Alessia Merra  1 , Maria Benedetta Rizzarda Maffezzoni  2 , Lorena Losi  3 , Vincenzo Giuseppe Genna  1 , Virginia Sceberras  1 , Graziella Pellegrini  1   2
Affiliations
Review

Regenerative Medicine of Epithelia: Lessons From the Past and Future Goals

Eleonora Maurizi et al. Front Bioeng Biotechnol. .

Abstract

This article explores examples of successful and unsuccessful regenerative medicine on human epithelia. To evaluate the applications of the first regenerated tissues, the analysis of the past successes and failures addresses some pending issues and lay the groundwork for developing new therapies. Research should still be encouraged to fill the gap between pathologies, clinical applications and what regenerative medicine can attain with current knowledge.

Keywords: clinical applications; cornea; epidermolysis bullosa; epithelia; oral mucosa; regenerative medicine; salivary gland; trachea.

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Conflict of interest statement

EM, FM, AM, VG, VS, and GP are employees of Holostem Terapie Avanzate, producing an Advanced Therapy Medicinal Product for corneal restoration. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Haematoxylin and Eosin images of the described epithelia. (A) Cornea (B) Oral cavity (C) Trachea (D) Intestine (E) Urethra (F) Skin (G) Salivary gland.
FIGURE 2
FIGURE 2
Graphic representation of the distance between research and routine clinical application of the described epithelia. Designed by PoweredTemplate.
See this image and copyright information in PMC

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