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Case Reports
. 2021 Jan-Dec:9:23247096211008593.
doi: 10.1177/23247096211008593.

Primary Pulmonary Undifferentiated Pleomorphic Sarcoma: A Rare Malignant Lung Tumor

Do Kyun Kang  1 , Min Kyun Kang  1 , Woon Heo  1 , Youn-Ho Hwang  1 , Ji Yeon Kim  1
Affiliations
Case Reports

Primary Pulmonary Undifferentiated Pleomorphic Sarcoma: A Rare Malignant Lung Tumor

Do Kyun Kang et al. J Investig Med High Impact Case Rep. 2021 Jan-Dec.

Abstract

We report a case of a 56-year-old man with persistent right upper lobe cavitary mass. A chest computed tomography scan showed about 4-cm-sized mass with internal low attenuation and peripheral enhancement in right upper lobe apical segment. The lesion size increased over 1 month. Right upper lobectomy was performed with the intention to treat the lesion. Pathological examination showed primary pulmonary undifferentiated pleomorphic sarcoma. We describe this rare lung disease to remind that primary pulmonary undifferentiated pleomorphic sarcoma could be the differential diagnosis of pulmonary cavitary mass lesions.

Keywords: lobectomy; malignant fibrous histiocytoma; undifferentiated pleomorphic sarcoma.

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Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
A preoperative chest computed tomography scan shows about 4-cm-sized mass with internal low attenuation and peripheral enhancement in right upper lobe apical segment (A, arrow). A positron emission tomography-computed tomography scan shows a well-defined lesion with intense fluorodeoxyglucose uptake in right upper lobe (B, arrow).
Figure 2.
Figure 2.
Gross photograph of the wedge resection specimen shows an ill-demarcated yellow-tan solid mass with hemorrhage and necrosis (A). Microscopically, the ill-defined tumor is bordered by thick inflamed tissue containing lymphoid follicles (B, red: tumor, blue: lymphoid follicles, yellow: lung parenchyma). The pleomorphic tumor cells show numerous neutrophils infiltrate. Note the frequent mitotic figures (C, yellow arrows). Tumor cell necrosis is seen, which is a feature of high-grade sarcoma (D). Immunostaining for vimentin reveals diffuse strong cytoplasmic staining (E). Immunohistochemistry for pancytokeratin is negative in tumor cells, while remaining pneumocytes and bronchiolar epithelium show normal expression (F).
See this image and copyright information in PMC

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