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. 2021 Apr 12;21(3):15357597211004549.
doi: 10.1177/15357597211004549. Online ahead of print.

Proceedings of the Sleep and Epilepsy Workgroup: Section 2 Comorbidities: Sleep Related Comorbidities of Epilepsy

Milena K Pavlova  1 , Marcus Ng  2   3 , Rebecca M Allen  4 , Melanie Boly  5 , Sanjeev Kothare  6 , Hiten Zaveri  7 , Phyllis C Zee  8 , Gail Adler  9 , Gordon F Buchanan  10 , Mark S Quigg  11
Affiliations

Proceedings of the Sleep and Epilepsy Workgroup: Section 2 Comorbidities: Sleep Related Comorbidities of Epilepsy

Milena K Pavlova et al. Epilepsy Curr. .

Abstract

Epilepsy is a chronic disease with multiple, complex comorbidities. Bidirectional relationships exist among seizures, sleep, circadian rhythms, and diseases within and outside of the central nervous system. Seizures fragment sleep and can contribute to development of sleep disorders, which in turn leads to worse overall health and more seizures. Moreover, treatment options are often limited by interactions with anti-seizure medications. Advances in the fields of epilepsy and in sleep medicine have been made separately, and therefore treating patients with these comorbidities necessitates interdisciplinary approach. The focus of this section of the Sleep and Epilepsy Workgroup was to identify methods of collaboration and outline investigational, educational, and treatment priorities to mutually advance what we consider a combined field.

Keywords: circadian rhythm; comorbidities; epilepsy; insomnia; sleep.

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Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Schematic of the multilateral relationships among sleep, circadian rhythms, and epilepsy divided into major domains of comorbidities.
See this image and copyright information in PMC

References

    1. Berg AT, Berkovic SF, Brodie MJ, et al. Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009. Epilepsia. 2010;51(4):676–685. - PubMed
    1. Latreille V, St. Louis EK, Pavlova M. Co-morbid sleep disorders and epilepsy: a narrative review and case examples. Epilepsy Res. 2018;145:185–197. - PubMed
    1. Latreille V, Abdennadher M, Dworetzky BA, et al. Nocturnal seizures are associated with more severe hypoxemia and increased risk of postictal generalized EEG suppression. Epilepsia. 2017;58(9):e127–e131. - PMC - PubMed
    1. Quigg M, Gharai S, Ruland J, et al. Insomnia in epilepsy is associated with continuing seizures and worse quality of life. Epilepsy Res. 2016;122:91–96. - PubMed
    1. Regestein Q, Natarajan V, Pavlova M, Kawasaki S, Gleason R, Koff E. Sleep debt and depression in female college students. Psychiatry Res. 2010;176(1):34–39. - PubMed

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