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. 2021 Sep;39(8):597-606.
doi: 10.1080/07357907.2021.1909059. Epub 2021 Jul 8.

Plasma D-Dimer and Fibrinogen Levels Correlates with Tumor Size and Disease Progression in Nigerian Breast Cancer Patients

Ogochukwu O Izuegbuna  1 , Olayide S Agodirin  2 , Hannah O Olawumi  1 , Samuel A Olatoke  2
Affiliations

Plasma D-Dimer and Fibrinogen Levels Correlates with Tumor Size and Disease Progression in Nigerian Breast Cancer Patients

Ogochukwu O Izuegbuna et al. Cancer Invest. 2021 Sep.

Abstract

Fourty-five breast cancer patients and 50 apparently healthy sex-matched controls from the University of Ilorin Teaching Hospital were enrolled in this study. Plasma D-dimer and fibrinogen were found to be significantly higher than controls; APTT was significantly shorter than the controls. D-dimer and fibrinogen were also significantly positively correlated with ECOG, disease stage, lymph node involvement, and tumor size. On multivariate analysis, D-dimer and fibrinogen were found to be independently related to lymph node involvement. This study shows that plasma D-dimer and fibrinogen levels are elevated in breast cancer patients, and both are markers of disease progression.

Keywords: D-dimer; D-dimer-fibrinogen ratio; breast cancer; fibrinogen; lymph nodes.

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