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. 2022 Mar;27(2):505-514.
doi: 10.1007/s40519-021-01187-4. Epub 2021 Apr 12.

Association of visceral adiposity index with new-onset type 2 diabetes and impaired fasting glucose in hypertensive Chinese adults

Chun Zhou  1 , Zhuxian Zhang  1 , Mengyi Liu  1 , Yuanyuan Zhang  1 , Panpan He  1 , Qinqin Li  2 , Di Xie  1 , Min Liang  1 , Guobao Wang  1 , Jing Nie  1 , Chengzhang Liu  3 , Yun Song  4 , Lishun Liu  4 , Binyan Wang  2 , Xiaobin Wang  5 , Xiping Xu  1   2   4 , Xianhui Qin  6
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Association of visceral adiposity index with new-onset type 2 diabetes and impaired fasting glucose in hypertensive Chinese adults

Chun Zhou et al. Eat Weight Disord. 2022 Mar.

Abstract

Purpose: Visceral adiposity index (VAI) is a reliable indicator for the distribution and function of adipose tissue in the body. The relation of VAI with new-onset type 2 diabetes and new-onset impaired fasting glucose (IFG) remains uncertain. We aimed to investigate the prospective relation of VAI with new-onset type 2 diabetes and new-onset IFG in Chinese hypertensive adults.

Methods: A total of 14,838 hypertensive adults free of type 2 diabetes at baseline were included from the China Stroke Primary Prevention Trial. The primary outcome was new-onset type 2 diabetes, defined as physician-diagnosed diabetes or use of glucose-lowering drugs during follow-up, or fasting glucose ≥ 7.0 mmol/L at the exit visit. The secondary outcome was new-onset IFG, defined as fasting glucose < 6.1 mmol/L at baseline, while fasting glucose ≥ 6.1 mmol/L and < 7.0 mmol/L at the exit visit.

Results: Over a median of 4.5 years' follow-up, 1612 (10.9%) participants developed type 2 diabetes. When VAI was categorized into quartiles, compared with participants in quartile 1-3 (< 2.80), significantly higher risk of new-onset type 2 diabetes (OR 1.30; 95% CI 1.08-1.56) and new-onset IFG (OR 1.28; 95% CI 1.08-1.52) was found in those in quartile 4 (≥ 2.80). Moreover, the positive associations were consistent in participants with or without single abnormal VAI components, including general obesity, abdominal obesity, elevated triglycerides and low high-density lipoprotein cholesterol (HDL-C) levels; or with different numbers of abnormal VAI components (all P interactions > 0.05).

Conclusion: Our study suggested a positive relation of VAI with the risk of new-onset type 2 diabetes and new-onset IFG in Chinese hypertensive patients, independent of its components.

Level of evidence: Level III, a well-designed cohort.

Keywords: Hypertension; New-onset impair fasting glucose; New-onset type 2 diabetes; Visceral adiposity index.

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