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Review
. 2021 Jul;48(7):980-985.
doi: 10.1111/cup.14025. Epub 2021 May 9.

Multiple myxoid cellular neurothekeomas in a patient with systemic lupus erythematosus

Sean K Lau  1 , David S Cassarino  2 , Stephen S Koh  1
Affiliations
Review

Multiple myxoid cellular neurothekeomas in a patient with systemic lupus erythematosus

Sean K Lau et al. J Cutan Pathol. 2021 Jul.

Abstract

Cellular neurothekeoma is a cutaneous tumor with a distinctive histopathologic appearance characterized by a dermal-based multinodular proliferation of epithelioid to spindled cells. Although the tumor may show varying amounts of myxoid stroma, extensive myxoid change is uncommon. The tumor typically presents as a solitary nodule with a predilection for the head and neck and upper limbs; examples of multiple cellular neurothekeomas are decidedly rare. The present report describes a unique case of multiple myxoid cellular neurothekeomas arising in a 60-year-old female with systemic lupus erythematosus. Two papular lesions were identified involving the skin inferior to the umbilicus and the left inguinal crease. Both lesions were histopathologically similar, forming a nodular mass composed of epithelioid cells in a prominent myxoid stroma. By immunohistochemistry the lesional cells expressed NKI/C3, microphthalmia transcription factor (MiTF), and CD68, with focal staining for PGP9.5, factor XIIIa, and CD10 also observed. The tumors were negative for S-100, SOX-10, epithelial membrane antigen, desmin, smooth muscle actin, glial fibrillary acid protein, and CD34. The present case confirms that cellular neurothekeoma can present clinically as multiple lesions and can have a predominantly myxoid appearance, potentially mimicking other cutaneous myxoid lesions.

Keywords: myxoid cellular neurothekeomas; systemic lupus erythematosus.

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References

REFERENCES

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