doi: 10.1016/0888-7543(88)90114-0.
The AKT1 proto-oncogene maps to human chromosome 14, band q32
Affiliations
- PMID: 3384441
- DOI: 10.1016/0888-7543(88)90114-0
Item in Clipboard
The AKT1 proto-oncogene maps to human chromosome 14, band q32
Genomics.
1988 Jan.
Abstract
The human AKT1 gene is the proto-oncogene of the viral oncogene v-akt. The AKT1 gene has been localized to human chromosome 14, band q32, proximal to the heavy-chain immunoglobulin locus (IGHM), by analysis of human-hamster somatic cell hybrids and by in situ hybridization. Chromosome rearrangements of this band which occur in T-lymphoid malignancies and Hodgkin's disease may affect the AKT1 gene.
Similar articles
-
The cellular homologue of the transforming gene of SKV avian retrovirus maps to human chromosome region 1q22----q24.Cytogenet Cell Genet. 1986;43(3-4):181-6. doi: 10.1159/000132318. Cytogenet Cell Genet. 1986. PMID: 3026737
-
The human VAV proto-oncogene maps to chromosome region 19p12----19p13.2.Hum Genet. 1990 Nov;86(1):65-8. doi: 10.1007/BF00205175. Hum Genet. 1990. PMID: 2253939
-
Concurrent activation of MYC and BCL2 in B cell non-Hodgkin lymphoma cell lines by translocation of both oncogenes to the same immunoglobulin heavy chain locus.Leukemia. 1996 Jul;10(7):1198-208. Leukemia. 1996. PMID: 8684002
-
Transforming genes of human malignancies.Carcinog Compr Surv. 1985;10:35-49. Carcinog Compr Surv. 1985. PMID: 2998614 Review. No abstract available.
-
Oncogenes and proto-oncogenes.J Cell Physiol Suppl. 1986;4:1-5. doi: 10.1002/jcp.1041290403. J Cell Physiol Suppl. 1986. PMID: 3528178 Review. No abstract available.
Cited by
-
Comparative map for mice and humans.Mamm Genome. 1992;3(9):480-536. doi: 10.1007/BF00778825. Mamm Genome. 1992. PMID: 1392257 Review. No abstract available.
-
Association between single nucleotide polymorphisms in the PI3K/AKT/mTOR pathway and bladder cancer risk in a sample of Iranian population.EXCLI J. 2018 Jan 2;17:3-13. doi: 10.17179/excli2017-329. eCollection 2018. EXCLI J. 2018. PMID: 29383014 Free PMC article.
-
Molecular docking appraisal of Dysphania ambrosioides phytochemicals as potential inhibitor of a key triple-negative breast cancer driver gene.In Silico Pharmacol. 2023 Jun 14;11(1):15. doi: 10.1007/s40203-023-00152-6. eCollection 2023. In Silico Pharmacol. 2023. PMID: 37323538 Free PMC article.
-
Akt Isoforms: A Family Affair in Breast Cancer.Cancers (Basel). 2021 Jul 9;13(14):3445. doi: 10.3390/cancers13143445. Cancers (Basel). 2021. PMID: 34298660 Free PMC article. Review.
-
Substrate preference of protein kinase B isoforms can vary depending on the cell line.PLoS One. 2024 Mar 19;19(3):e0298322. doi: 10.1371/journal.pone.0298322. eCollection 2024. PLoS One. 2024. PMID: 38502658 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Miscellaneous
