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Review
. 2022 Apr;289(8):2318-2336.
doi: 10.1111/febs.15872. Epub 2021 Apr 23.

Interneuron development and dysfunction

Jiaxin Yang  1 , Xiong Yang  1 , Ke Tang  1
Affiliations
Free article
Review

Interneuron development and dysfunction

Jiaxin Yang et al. FEBS J. 2022 Apr.
Free article

Abstract

Understanding excitation and inhibition balance in the brain begins with the tale of two basic types of neurons, glutamatergic projection neurons and GABAergic interneurons. The diversity of cortical interneurons is contributed by multiple origins in the ventral forebrain, various tangential migration routes, and complicated regulations of intrinsic factors, extrinsic signals, and activities. Abnormalities of interneuron development lead to dysfunction of interneurons and inhibitory circuits, which are highly associated with neurodevelopmental disorders including schizophrenia, autism spectrum disorders, and intellectual disability. In this review, we mainly discuss recent findings on the development of cortical interneuron and on neurodevelopmental disorders related to interneuron dysfunction.

Keywords: autism spectrum disorders; cerebral cortex; intellectual disability; interneuron; schizophrenia.

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