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Comment
. 2021 May;9(5):445-447.
doi: 10.1016/S2213-2600(21)00140-5. Epub 2021 Apr 9.

COVID-19 severity and obesity: are MAIT cells a factor?

Cormac McCarthy  1 , Cliona P O'Donnell  2 , Neil E Wrigley Kelly  3 , Donal O'Shea  3 , Andrew E Hogan  4
Affiliations
Comment

COVID-19 severity and obesity: are MAIT cells a factor?

Cormac McCarthy et al. Lancet Respir Med. 2021 May.
No abstract available

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Conflict of interest statement

We declare no competing interests. DOS and AEH are funded by the Health Research Board, Ireland. AEH is funded by the National Children's Research Centre, Ireland.

Figures

Figure
Figure
Role of MAIT cells in COVID-19 and obesity MAIT cells in (A) the lungs and (B) the peripheral blood of patients with COVID-19. (C) MAIT-cell response to adenovirus-vectored SARS-CoV-2 vaccine. (D) MAIT cells in the peripheral blood of people with obesity. CD=cluster of differentiation. DC=dendritic cell. IFN=interferon. IL=interleukin. MAIT cell=mucosal associated invariant T cell. PD-1=programmed cell death protein 1.
See this image and copyright information in PMC

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References

    1. Popkin BM, Du S, Green WD, et al. Individuals with obesity and COVID-19: a global perspective on the epidemiology and biological relationships. Obes Rev. 2020;21 - PMC - PubMed
    1. WHO Obesity and overweight. April 1, 2020. https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight
    1. Hotamisligil GS. Inflammation and metabolic disorders. Nature. 2006;444:860–867. - PubMed
    1. Tay MZ, Poh CM, Rénia L, MacAry PA, Ng LFP. The trinity of COVID-19: immunity, inflammation and intervention. Nat Rev Immunol. 2020;20:363–374. - PMC - PubMed
    1. O'Shea D, Hogan AE. Dysregulation of natural killer cells in obesity. Cancers (Basel) 2019;11:e573. - PMC - PubMed