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Randomized Controlled Trial
. 2021 Apr 12;22(1):272.
doi: 10.1186/s13063-021-05105-y.

The Early Youth Engagement in first episode psychosis (EYE-2) study: pragmatic cluster randomised controlled trial of implementation, effectiveness and cost-effectiveness of a team-based motivational engagement intervention to improve engagement

Kathryn Greenwood  1   2 , Rebecca Webb  3 , Jenny Gu  3 , David Fowler  4   3   5 , Richard de Visser  3 , Stephen Bremner  6 , Iga Abramowicz  6 , Nicky Perry  7 , Stuart Clark  8 , Anastacia O'Donnell  8 , Dan Charlton  8 , Rebecca Jarvis  8 , Philippa Garety  9   10 , Sunil Nandha  10 , Belinda Lennox  11   12 , Louise Johns  11   12 , Shanaya Rathod  13 , Peter Phiri  13 , Paul French  14   15 , Heather Law  16 , Jo Hodgekins  5 , Michelle Painter  17 , Cate Treise  17 , James Plaistow  18 , Francis Irwin  18 , Rose Thompson  19 , Tanya Mackay  19 , Carl R May  20 , Andy Healey  9 , Richard Hooper  21 , Emmanuelle Peters  9   10
Affiliations
Randomized Controlled Trial

The Early Youth Engagement in first episode psychosis (EYE-2) study: pragmatic cluster randomised controlled trial of implementation, effectiveness and cost-effectiveness of a team-based motivational engagement intervention to improve engagement

Kathryn Greenwood et al. Trials. .

Abstract

Background: Early Intervention in Psychosis (EIP) services improve health outcomes for young people with psychosis in the medium-long term, but 25% of young people disengage in the first 12 months with costs to their mental health, families, society and the NHS. This study will evaluate the effectiveness, cost-effectiveness and implementation of a team-based motivational Early Youth Engagement (EYE-2) intervention.

Method: The study design is a cluster randomised controlled trial (RCT) with economic evaluation, comparing the EYE-2 intervention + standardised EIP service to standardised EIP service alone, with randomisation at the team level. A process evaluation will evaluate the delivery of the intervention qualitatively and quantitatively across contexts. The setting is 20 EIP teams in 5 sites: Manchester, South London, East Anglia, Thames Valley and Hampshire. Participants are young people (14-35 years) with first episode psychosis, and EIP staff. The intervention is the team-based motivational engagement (EYE-2) intervention, delivered alongside standardised EIP services, and supported by additional training, website, booklets and social groups. The comparator is the standardised EIP service. Both interventions are delivered by EIP clinicians. The primary outcome is time to disengagement (time in days from date of allocation to care coordinator to date of last contact following refusal to engage with EIP service, or lack of response to EIP contact for a consecutive 3-month period). Secondary outcomes include mental and physical health, deaths, social and occupational function, recovery, satisfaction and service use at 6, 12, 18 and 24 months. A 12-month within-trial economic evaluation will investigate cost-effectiveness from a societal perspective and from an NHS perspective.

Discussion: The trial will provide the first test of an engagement intervention in standardised care, with the potential for significant impact on the mental health and wellbeing of young people and their families, and economic benefits for services. The intervention will be highly scalable, supported by the toolkit including manuals, commissioning guide, training and resources, adapted to meet the needs of the diverse EIP population, and based on an in-depth process evaluation.

Trial registration: ISRCTN 51629746 prospectively registered 7th May 2019. Date assigned 10th May 2019.

Keywords: Early intervention; Economic evaluation; Engagement; Intervention; Process evaluation; Psychosis; RCT.

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Figures

Fig. 1
Fig. 1
SPIRIT figure. aRoutinely recorded by service and collated by RAs in teams. bRoutinely collected by clinicians and collated by RAs in teams. cCollected by RAs for AD-SUS, people who disengage, and missing data
Fig. 2
Fig. 2
EYE-2 intervention booklets for service users
Fig. 3
Fig. 3
Homepage of the EYE-2 website for service users
See this image and copyright information in PMC

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References

    1. Sartorius N, Jablensky A, Korten A, Ernberg G, Anker M, Cooper JE, Day R. Early manifestations and first-contact incidence of schizophrenia in different cultures: a preliminary report on the initial evaluation phase of the WHO collaborative study on determinants of outcome of severe mental disorders. Psychol Med. 1986;16(4):909–928. doi: 10.1017/S0033291700011910. - DOI - PubMed
    1. Department of Health. The NHS Plan: a plan for investment, a plan for reform. London: Stationery Office; 2000.
    1. Rössler W, Salize HJ, van Os J, Riecher-Rössler A. Size of burden of schizophrenia and psychotic disorders. Eur Neuropsychopharmacol. 2005;15(4):399–409. doi: 10.1016/j.euroneuro.2005.04.009. - DOI - PubMed
    1. Parks J, Svendsen D, Singer P, Foti ME, Mauer B. Morbidity and mortality in people with serious mental illness. Alexandria, VA: National Association of State Mental Health Program Directors (NASMHPD) Medical Directors Council; 2006. pp. 1–87.
    1. Wiersma D, Nienhuis FJ, Slooff CJ, Giel R. Natural course of schizophrenic disorders: a 15-year followup of a Dutch incidence cohort. Schizophr Bull. 1998;24(1):75–85. doi: 10.1093/oxfordjournals.schbul.a033315. - DOI - PubMed

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