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. 2021 Sep;69(3):457-464.
doi: 10.1016/j.jadohealth.2020.12.138. Epub 2021 Apr 10.

Clinician Recognition of First Episode Psychosis

Affiliations

Clinician Recognition of First Episode Psychosis

Kathryn Albin et al. J Adolesc Health. 2021 Sep.

Abstract

Purpose: Psychotic disorders develop during mid-adolescence through early adulthood, with the initial few months a "critical period" offering the greatest promise for recovery. However, the duration of untreated psychosis is typically over a year. This study aimed to identify aspects of care episodes contributing to delays in diagnosis of a first psychotic episode.

Methods: Study subjects included 161 adolescents and young adults referred to a first episode psychosis treatment program. We captured the various ways that people who experience a severe mental illness engage in treatment using standardized interviews with patients and informants (e.g., family member) and medical record review.

Results: A psychotic disorder diagnosis was not given for 38% of subjects at their initial episode of care. Time to first care episode was virtually the same for subjects that did and did not receive a psychosis diagnosis; 50% within 1 month and 84% within 6 months. Compared to initial care episodes with a psychosis diagnosis, those without a psychosis diagnosis less often involved emergency services (80% vs. 38%, respectively; p value = 1 × 10-7) and more often outpatient primary care (6% vs. 18%; p value = .032) and mental health (32% vs. 49%; p value = .045) services. However, dangerousness indicators were similar (29% vs. 28%; p value = 1). Dangerousness indicators increased to 54% (p value = .002) by the time of eventual diagnosis for those requiring multiple care episodes.

Conclusions: Clinicians were important contributors to delays in diagnosis and treatment of psychosis. Interventions targeting outpatient health care providers may be fruitful in reducing the duration of untreated psychosis.

Keywords: Adolescent mental health; Duration of untreated psychosis; First episode psychosis; Treatment delays.

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Conflict of interest statement

Disclosures: Dr. Perkins has served as a consultant for Sunovion and Alkermes, received research support from Boehringer-Ingelheim, and has received royalties from American Psychiatric Association Publishing. The other authors report no financial relationships with commercial interests.

Figures

Figure 1
Figure 1
a Duration of Untreated Psychosis. First Care Episode Psychosis Diagnosis versus First Care Episode No Psychosis Diagnosis b Duration of Untreated Psychosis. First Care Episode Psychosis Diagnosis versus Psychosis Diagnosis Care Episode, Multiple Care Episodes

References

    1. Perkins DO, Gu H, Boteva K, et al. Relationship between duration of untreated psychosis and outcome in first-episode schizophrenia: a critical review and meta-analysis. Am J Psychiatry 2005;162:1785–1804. - PubMed
    1. Sullivan SA, Carroll R, Peters TJ, et al. Duration of untreated psychosis and clinical outcomes of first episode psychosis: An observational and an instrumental variables analysis. Early Interv Psychiatry 2018. - PubMed
    1. Marino L, Scodes J, Ngo H, et al. Determinants of pathways to care among young adults with early psychosis entering a coordinated specialty care program. Early Interv Psychiatry 2019. - PubMed
    1. Bertolote J, McGorry P. Early intervention and recovery for young people with early psychosis: consensus statement. Br J Psychiatry Suppl 2005;48:s116–119. - PubMed
    1. Crumlish N, Whitty P, Clarke M, et al. Beyond the critical period: longitudinal study of 8-year outcome in first-episode non-affective psychosis. Br J Psychiatry 2009;194:18–24. - PubMed

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