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. 2021 Apr 12;11(4):73.
doi: 10.1038/s41408-021-00464-w.

Octogenarian newly diagnosed multiple myeloma patients without geriatric impairments: the role of age >80 in the IMWG frailty score

Affiliations

Octogenarian newly diagnosed multiple myeloma patients without geriatric impairments: the role of age >80 in the IMWG frailty score

Mattia D'Agostino et al. Blood Cancer J. .
No abstract available

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Conflict of interest statement

M.D. has received honoraria for lectures from Sanofi and GSK; has served on the advisory boards for GSK. A.L. has received honoraria from Amgen, Bristol-Myers Squibb, Celgene, Janssen, and GSK; has served on the advisory boards for Bristol-Myers Squibb, Celgene, Janssen, and Takeda. M.O. has received honoraria from Amgen, Bristol-Myers Squibb, Celgene, Janssen, GSK, Sanofi, and Takeda; has served on the advisory boards for Amgen, Bristol-Myers Squibb, Celgene, Janssen, GSK, Sanofi, and Takeda. A.M.L. has received personal fees from Incyte; has received research funding from Novartis, Janssen, AbbVie, Roche, Celgene, Amgen, Bristol-Myers Squibb, Takeda, Incyte, Pfizer, Beigene, Oncopeptides, Verastem, Karyopharm, Archigen, Biopharma, Debiopharm, Morphosys, Fibrogen, and Onconova. G.G. has served on the advisory boards for Janssen, AbbVie, and AstraZeneca; has served on the speaker’s bureaus for Janssen and AbbVie. M.T.P. has received honoraria from and served on the advisory boards for Celgene, Janssen-Cilag, Amgen, Bristol-Myers Squibb, Takeda, Sanofi, and GSK. R.Z. has served on the advisory boards for Janssen and Celgene. F.P. has served on the advisory boards for Celgene and Janssen. G.B. has received honoraria from Novartis, Celgene Amgen, and Takeda. N.G. has received research grants from Celgene and Janssen Pharmaceutica; has received sponsorship for clinical studies from Janssen Pharmaceutica, Millennium Pharmaceuticals, and GSK; has served on the advisory boards for Celgene, Takeda, and Janssen Pharmaceutica; has received support for participating in meetings from Janssen Pharmaceutica, Celgene, and Bristol-Myers Squibb. F.D.R. has received honoraria from Celgene, Janssen, Amgen, and Takeda. P.C. has participated as a lecturer and/or has served on the advisory boards for AbbVie, ADC Therapeutics, Amgen, Celgene, Daiichi Sankyo, Gilead, Incyte, Janssen, Jazz Pharmaceuticals, Kite, Kyowa Kirin, Novartis, Roche, Sanofi, Servier, and Takeda. P.M. has received honoraria and/or served on the scientific advisory boards for Celgene, Janssen, Takeda, Bristol-Myers Squibb, Amgen, Novartis, Gilead, Jazz, Sanofi, AbbVie, and Glaxo-Smith-Kline. R.H. has had a consultant or advisory relationship with Janssen, Amgen, Celgene, AbbVie, BMS, Novartis, PharmaMar, and Takeda; has received honoraria from Janssen, Amgen, Celgene, BMS, PharmaMar, and Takeda; has received research funding from Janssen, Amgen, Celgene, BMS, Novartis, and Takeda. P.S. has served on the advisory boards for Amgen, Celgene, Genenta, Janssen, Seattle Genetics, Takeda, and Karyopharm. M.B. has received honoraria from Sanofi, Celgene, Amgen, Janssen, Novartis, Bristol-Myers Squibb, and AbbVie; has served on the advisory boards for Janssen and GSK; has received research funding from Sanofi, Celgene, Amgen, Janssen, Novartis, Bristol-Myers Squibb, and Mundipharma. S.B. has received honoraria from Celgene, Amgen, Janssen, and Bristol-Myers Squibb; has served on the advisory boards for Celgene, Amgen, Janssen, and Karyopharm; has received consultancy fees from Janssen and Takeda. The remaining authors declare no competing interests.

Figures

Fig. 1
Fig. 1. Outcomes of patients according to frailty group.
Overall survival (A), cumulative incidence of drug discontinuation for any cause excluding progression and death (B), and survival analysis by time from diagnosis (C, D). OS overall survival, HR hazard ratio, CI confidence interval, p p-value.

References

    1. Larocca A, et al. Patient-centered practice in elderly myeloma patients: an overview and consensus from the European Myeloma Network (EMN) Leukemia. 2018;32:1697–1712. doi: 10.1038/s41375-018-0142-9. - DOI - PubMed
    1. Salvini M, D’Agostino M, Bonello F, Boccadoro M, Bringhen S. Determining treatment intensity in elderly patients with multiple myeloma. Expert Rev. Anticancer Ther. 2018;18:917–930. doi: 10.1080/14737140.2018.1496823. - DOI - PubMed
    1. Palumbo A, et al. Geriatric assessment predicts survival and toxicities in elderly myeloma patients: an International Myeloma Working Group report. Blood. 2015;125:2068–2074. doi: 10.1182/blood-2014-12-615187. - DOI - PMC - PubMed
    1. Bringhen S, et al. Lenalidomide-based induction and maintenance in elderly newly diagnosed multiple myeloma patients: updated results of the EMN01 randomized trial. Haematologica. 2020;105:1937–1947. doi: 10.3324/haematol.2019.226407. - DOI - PMC - PubMed
    1. Larocca A, et al. A phase 2 study of three low-dose intensity subcutaneous bortezomib regimens in elderly frail patients with untreated multiple myeloma. Leukemia. 2016;30:1320–1326. doi: 10.1038/leu.2016.36. - DOI - PubMed