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. 2021 Apr 12;11(1):7884.
doi: 10.1038/s41598-021-86963-z.

COPD significantly increases cerebral and cardiovascular events in hypertensives

Maria Perticone #  1 , Raffaele Maio #  2 , Benedetto Caroleo  2 , Edoardo Suraci  1 , Salvatore Corrao  3 , Giorgio Sesti  4 , Francesco Perticone  5
Affiliations

COPD significantly increases cerebral and cardiovascular events in hypertensives

Maria Perticone et al. Sci Rep. .

Abstract

Essential hypertension and chronic obstructive pulmonary disease often coexist in the same patient. The aim of this study was to evaluate whether the addition of chronic obstructive pulmonary disease modifies the risk of cardiovascular events in hypertensives. We enrolled 1728 hypertensives. Study outcomes included fatal and non-fatal cardiovascular stroke and myocardial infarction, and cardiovascular death. During a mean follow-up of 57 months there were 205 major adverse cardiovascular events (2.47 per 100 pts/yr): cardiac (n117; 1.41 per 100 pts/yr) and cerebrovascular (n = 77; 0.93 per 100 pts/yr). In hypertensives with chronic obstructive pulmonary disease we observed a greater number of cardiovascular events than in hypertensives without respiratory disease (133 [5.55 per 100 pts/yr) vs 72 [1.22 per 100 pts/yr], respectively. The addition of chronic obstructive pulmonary disease to hypertension increased the incidence of total and non-fatal stroke of more than nine- (2.42 vs 0.32 per 100 pts/yr) and 11-fold (2.09 vs 0.22 per 100 pts/yr), respectively. The same trend was observed for total (2.88 vs 0.81 per 100 pts/yr) and non-fatal (2.67 vs 0.79 per 100 pts/y) myocardial infarction. The presence of chronic obstructive pulmonary disease in hypertensives significantly increases the risk of stroke, myocardial infarction and major adverse cardiovascular events.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Kaplan–Meier curves for MACE (A), total myocardial infarction (B) and total stroke (C) in hypertensive patients with and without COPD.
Figure 2
Figure 2
Flow chart of patients enrollment.
See this image and copyright information in PMC

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