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Review
. 2021;27(3):1689-1697.
doi: 10.1007/s10989-021-10201-3. Epub 2021 Apr 8.

Outer Membrane Protein-Coated Nanoparticles as Antibacterial Vaccine Candidates

Majid Anwar  1 , Faqir Muhammad  1 , Bushra Akhtar  2 , Muhammad Irfan Anwar  3 , Ahmad Raza  4 , Abdul Aleem  1
Affiliations
Review

Outer Membrane Protein-Coated Nanoparticles as Antibacterial Vaccine Candidates

Majid Anwar et al. Int J Pept Res Ther. 2021.

Abstract

Nanoformulations are novel therapeutic strategies as compared to traditional treatments. The development of biomimetic nanoparticles by combining the natural cellular material with synthetic nanoparticles has inspired innovative vaccine strategies for modifying the antibacterial immunity. A lot of work has been done in which synthetic nanoparticles are coated with biomimetic cellular membranes for enhancement of biological functions and treatments. Outer membrane protein of bacteria not only act as adjuvant but also contain a large number of immunogenic antigens that play an important role in motivating the native immunity and stimulating the immune responses of the body. Outer membrane protein coating onto the surfaces of synthetic nanoparticles has synergistic effects to produce antibacterial responses. This article reviews the recent improvements related to the bacterial membrane-coated nanoparticles for antibacterial immunization.

Keywords: Biomimetic nanoparticles; Membrane coating; Nanoformulation; Outer membrane.

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Conflict of interest statement

Conflict of interestAll authors declared that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Bacterial cell envelope possesses two membranes around the cytoplasm. A typical symmetric glycerophospholipid bilayer of inner membrane (IM) and asymmetric bilayer of outer membrane (OM) containing an inner leaflet of glycerophospholipid and an outer leaflet containing lipopolysaccharide (LPS)
Fig. 2
Fig. 2
Demonstration of coating of different types of bacterial outer membrane on the surface of various shapes nanoparticles
See this image and copyright information in PMC

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