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Review
. 2021 Jul;42(7):2653-2660.
doi: 10.1007/s10072-021-05234-x. Epub 2021 Apr 12.

Nanoparticles approaches in neurodegenerative diseases diagnosis and treatment

Zahra Asefy  1 , Sirus Hoseinnejhad  2 , Zaker Ceferov  3
Affiliations
Review

Nanoparticles approaches in neurodegenerative diseases diagnosis and treatment

Zahra Asefy et al. Neurol Sci. 2021 Jul.

Abstract

The World Health Organization (WHO) has declared that neurodegenerative diseases will be the biggest health issues of the twenty-first century. Among these, Alzheimer's and Parkinson's diseases can be considered as the most acute incurable neurological diseases. Researchers are studying and developing a new treatment approach that uses nanotechnology to diagnosis and treatment neurodegenerative diseases. This treatment strategy will be used to regress neurodegenerative diseases such as Alzheimer's disease. Alzheimer's disease (AD) is one of the most common forms of reduced brain function, which causes many devastating complications. Current neurodegenerative diseases treatment protocols only help to treat symptoms nevertheless with nanotechnology approaches, can regress nerve cells apoptosis, reduce inflammation, and improve brain drug delivery. In this paper, new nanotechnology methods such as nanobodies, nano-antibodies, and lipid nanoparticles have been investigated. Correspondingly blood-brain barrier drug delivery improvement methods have been suggested.

Keywords: Nanoparticles; Neurodegenerative diseases.

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