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Comparative Study
. 2021 Apr 12;36(14):e101.
doi: 10.3346/jkms.2021.36.e101.

Clinical Application of the Standard Q COVID-19 Ag Test for the Detection of SARS-CoV-2 Infection

Sang Min Oh  1 , Hyeonju Jeong  1 , Euijin Chang  1 , Pyoeng Gyun Choe  1 , Chang Kyung Kang  1 , Wan Beom Park  1 , Taek Soo Kim  2 , Woon Yong Kwon  3 , Myoung Don Oh  1 , Nam Joong Kim  4
Affiliations
Comparative Study

Clinical Application of the Standard Q COVID-19 Ag Test for the Detection of SARS-CoV-2 Infection

Sang Min Oh et al. J Korean Med Sci. .

Abstract

We evaluated the Standard Q COVID-19 Ag test for the diagnosis of coronavirus disease 2019 (COVID-19) compared to the reverse transcription-polymerase chain reaction (RT-PCR) test. We applied both tests to patients who were about to be hospitalized, had visited an emergency room, or had been admitted due to COVID-19 confirmed by RT-PCR. Two nasopharyngeal swabs were obtained; one was tested by RT-PCR and the other by the Standard Q COVID-19 Ag test. A total of 118 pairs of tests from 98 patients were performed between January 5 and 11, 2021. The overall sensitivity and specificity for detecting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) for the Standard Q COVID-19 Ag test compared to RT-PCR were 17.5% (95% confidence interval [CI], 8.8-32.0%) and 100% (95% CI, 95.3-100.0%). Analysis of the results using RT-PCR cycle thresholds of ≤ 30 or ≤ 25 increased the sensitivity to 26.9% (95% CI, 13.7-46.1%), and 41.1% (95% CI, 21.6-64.0%), respectively.

Keywords: Antigen Test; COVID-19; SARS-CoV-2.

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Conflict of interest statement

The authors have no potential conflicts of interest to disclose.

Figures

Fig. 1
Fig. 1. Post-test probability of severe acute respiratory syndrome coronavirus 2 infection, given a negative test result, according to variable sensitivities.
See this image and copyright information in PMC

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