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Observational Study
. 2021 Jul;56(7):2195-2203.
doi: 10.1002/ppul.25422. Epub 2021 Apr 26.

Is viral coinfection a risk factor for severe lower respiratory tract infection? A retrospective observational study

Aykut Eşki  1 , Gökçen Kartal Öztürk  2 , Candan Çiçek  3 , Figen Gülen  2 , Esen Demir  2
Affiliations
Observational Study

Is viral coinfection a risk factor for severe lower respiratory tract infection? A retrospective observational study

Aykut Eşki et al. Pediatr Pulmonol. 2021 Jul.

Abstract

Objective: To determine whether viral coinfection is a risk for severe lower respiratory tract infection (LRTI).

Working hypothesis: Children with viral coinfection had a higher risk for admission to the intensive care unit (ICU) than those with a single virus infection.

Study design: Retrospective, observational study for 10 years.

Patient-subject selection: Children between 1 and 60 months of age hospitalized with LRTI.

Keywords: influenza virus; intensive care unit; lower respiratory tract infection; respiratory syncytial virus; rhinovirus.

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Conflict of interest statement

The authors declare that there are no conflict of interests.

Figures

Figure 1
Figure 1
The study flow diagram
Figure 2
Figure 2
Comparison of virus coinfection with single virus infection
Figure 3
Figure 3
Subgroup regression analysis of each virus coinfection by age between 1 and 3 months
Figure 4
Figure 4
Subgroup regression analysis of each virus coinfection by age between 4 and 6 months
Figure 5
Figure 5
Subgroup regression analysis of each virus coinfection by age between 7 and 12 months
See this image and copyright information in PMC

References

    1. Ruuskanen O, Lahti E, Jennings LC, Murdoch DR. Viral pneumonia. Lancet. 2011;377(9773):1264‐1275. - PMC - PubMed
    1. Singleton RJ, Holman RC, Folkema AM, Wenger JD, Steiner CA, Redd JT. Trends in lower respiratory tract infection hospitalizations among American Indian/Alaska Native children and the general US child population. J Pediatr. 2012;161(2):296‐302. - PubMed
    1. Hasegawa K, Tsugawa Y, Brown DFM, Mansbach JM, Camargo CA. Trends in bronchiolitis hospitalizations in the United States, 2000‐2009. Pediatrics. 2013;132(1):28‐36. - PMC - PubMed
    1. Florin TA, Plint AC, Zorc JJ. Viral bronchiolitis. Lancet. 2017;389(10065):211‐224. - PMC - PubMed
    1. Asner SA, Science ME, Tran D, Smieja M, Merglen A, Mertz D. Clinical disease severity of respiratory viral coinfection versus single viral infection: a systematic review and meta‐analysis. PLoS One. 2014;9(6):e99392. - PMC - PubMed

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