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Meta-Analysis
. 2021 Apr 16;100(15):e25531.
doi: 10.1097/MD.0000000000025531.

Analgesic comparison of dezocine plus propofol versus fentanyl plus propofol for gastrointestinal endoscopy: A meta-analysis

Lin Zhang  1 , Chun Li  2 , Chuncheng Zhao  1 , Zhengzhong Zhao  1 , Yi Feng  1
Affiliations
Meta-Analysis

Analgesic comparison of dezocine plus propofol versus fentanyl plus propofol for gastrointestinal endoscopy: A meta-analysis

Lin Zhang et al. Medicine (Baltimore). .

Abstract

Introduction: As the adjunctive anesthesia to propofol, both dezocine and fentanyl showed some potential for gastrointestinal endoscopy. This meta-analysis aimed to compare their efficacy and safety.

Methods: PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases were systematically searched. Randomized controlled trials (RCTs) assessing the effect of dezocine versus fentanyl for the anesthesia of patients undergoing gastrointestinal endoscopy were included.

Results: Five RCTs involving 677 patients were included in the meta-analysis. Overall, compared with fentanyl plus propofol for gastrointestinal endoscopy, dezocine plus propofol resulted in the reduction in propofol dose(mean difference [MD] = -11.72; 95% confidence interval [CI] = -22.83 to -0.61; P = .04), awakening time (std. MD = -1.79; 95% CI = -3.31 to -0.27; P = .02) and hypopnea (risk ratio [RR] = 0.16; 95% CI = 0.06-0.41; P = .0002), but had no remarkable effect on induction time (MD = 1.20; 95% CI = -0.98 to 3.39; P = .28), postoperative pain score (MD = -0.38; 95% CI = -1.00 to 0.24; P = .24), nausea or vomiting (RR = 0.45; 95% CI = 0.10-1.98; P = .29).

Conclusion: Dezocine plus propofol may be better for the anesthesia of gastrointestinal endoscopy than fentanyl plus propofol.

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Conflict of interest statement

The authors report no conflicts of interest.

Figures

Figure 1
Figure 1
Flow diagram of study searching, selection process and analysis.
Figure 2
Figure 2
Forest plot for the meta-analysis of propofol dose (mg).
Figure 3
Figure 3
Forest plot for the meta-analysis of awakening time (s).
Figure 4
Figure 4
Forest plot for the meta-analysis of induction time (s).
Figure 5
Figure 5
Forest plot for the meta-analysis of postoperative pain score.
Figure 6
Figure 6
Forest plot for the meta-analysis of hypopnea.
Figure 7
Figure 7
Forest plot for the meta-analysis of nausea and vomiting.
See this image and copyright information in PMC

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