Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2021 Jul 13;106(8):e3269-e3271.
doi: 10.1210/clinem/dgab246.

T4DM Trial and its T4Bone Substudy Shed Further Light on Effects of Testosterone Treatment in Middle-Aged and Older Men

Shalender Bhasin  1 , Peter J Snyder  2
Affiliations
Editorial

T4DM Trial and its T4Bone Substudy Shed Further Light on Effects of Testosterone Treatment in Middle-Aged and Older Men

Shalender Bhasin et al. J Clin Endocrinol Metab. .
No abstract available

Keywords: T4DM; bone; microarchitecture; testosterone.

PubMed Disclaimer

Comment on

References

    1. Snyder PJ, Bhasin S, Cunningham GR, et al. ; Testosterone Trials Investigators . Effects of testosterone treatment in older men. N Engl J Med. 2016;374(7):611-624. - PMC - PubMed
    1. Ng Tang Fui M, Hoermann R, Bracken K, et al. Effect of Testosterone treatment on bone microarchitecture and bone mineral density in men: a two-year RCT. J Clin Endocrinol Metab. 2021:dgab149. doi: 10.1210/clinem/dgab149. - DOI - PubMed
    1. Wittert G, Bracken K, Robledo KP, et al. Testosterone treatment to prevent or revert type 2 diabetes in men enrolled in a lifestyle programme (T4DM): a randomised, double-blind, placebo-controlled, 2-year, phase 3b trial. Lancet Diabetes Endocrinol. 2021;9(1):32-45. - PubMed
    1. Snyder PJ, Kopperdahl DL, Stephens-Shields AJ, et al. Effect of testosterone treatment on volumetric bone density and strength in older men with low testosterone: a controlled clinical trial. JAMA Intern Med. 2017;177(4):471-479. doi:10.1001/jamainternmed.2016.9539. Erratum in: JAMA Intern Med. 2017;177(4):600. Erratum in: JAMA Intern Med. 2019;179(3):457. - PMC - PubMed
    1. Al Mukaddam M, Rajapakse CS, Bhagat YA, et al. Effects of testosterone and growth hormone on the structural and mechanical properties of bone by micro-MRI in the distal tibia of men with hypopituitarism. J Clin Endocrinol Metab. 2014;99(4):1236-1244. - PMC - PubMed