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Comment
. 2021 Apr 12;39(4):453-456.
doi: 10.1016/j.ccell.2021.03.003.

A rational targeted therapy for platinum-resistant small-cell lung cancer

Benjamin J Drapkin  1 , John D Minna  2
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Comment

A rational targeted therapy for platinum-resistant small-cell lung cancer

Benjamin J Drapkin et al. Cancer Cell. .
Free article

Abstract

Small-cell lung cancer (SCLC) is initially sensitive to platinum doublet chemotherapy, providing dramatic clinical benefit. Unfortunately, most SCLCs relapse and become resistant to further therapy. In this issue of Cancer Cell, Thomas et al. show that some platinum-resistant SCLCs benefit from combination therapy with topotecan plus the ATR (ataxia telangiectasia-mutated and rad3-related) inhibitor berzosertib.

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Conflict of interest statement

Declaration of interests J.D.M. receives NCI and UT Southwestern licensing royalties for distribution of human tumor lines.

Comment on

  • Therapeutic targeting of ATR yields durable regressions in small cell lung cancers with high replication stress.
    Thomas A, Takahashi N, Rajapakse VN, Zhang X, Sun Y, Ceribelli M, Wilson KM, Zhang Y, Beck E, Sciuto L, Nichols S, Elenbaas B, Puc J, Dahmen H, Zimmermann A, Varonin J, Schultz CW, Kim S, Shimellis H, Desai P, Klumpp-Thomas C, Chen L, Travers J, McKnight C, Michael S, Itkin Z, Lee S, Yuno A, Lee MJ, Redon CE, Kindrick JD, Peer CJ, Wei JS, Aladjem MI, Figg WD, Steinberg SM, Trepel JB, Zenke FT, Pommier Y, Khan J, Thomas CJ. Thomas A, et al. Cancer Cell. 2021 Apr 12;39(4):566-579.e7. doi: 10.1016/j.ccell.2021.02.014. Cancer Cell. 2021. PMID: 33848478 Free PMC article.

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