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Comment
. 2021 Apr 12;39(4):460-462.
doi: 10.1016/j.ccell.2021.03.001.

Glucose makes Treg lose their temper

Matteo Villa  1 , David O'Sullivan  2 , Erika L Pearce  3
Affiliations
Free article
Comment

Glucose makes Treg lose their temper

Matteo Villa et al. Cancer Cell. .
Free article

Abstract

Competition for glucose regulates the balance between cancer and immune responses. New findings published in Nature show that regulatory T cells (Treg) shape their metabolism to avoid glucose competition, thus maintaining their stability and sustaining tumor progression. This research suggests hijacking the "eating habits" of Treg could improve cancer therapy.

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Conflict of interest statement

Declaration of interests E.L.P. is an SAB member of Immunomet and a founder and advisor of Rheos Medicines. A family member of E.L.P. is a founder and advisor of Rheos Medicines.

Comment on

  • CTLA-4 blockade drives loss of Treg stability in glycolysis-low tumours.
    Zappasodi R, Serganova I, Cohen IJ, Maeda M, Shindo M, Senbabaoglu Y, Watson MJ, Leftin A, Maniyar R, Verma S, Lubin M, Ko M, Mane MM, Zhong H, Liu C, Ghosh A, Abu-Akeel M, Ackerstaff E, Koutcher JA, Ho PC, Delgoffe GM, Blasberg R, Wolchok JD, Merghoub T. Zappasodi R, et al. Nature. 2021 Mar;591(7851):652-658. doi: 10.1038/s41586-021-03326-4. Epub 2021 Feb 15. Nature. 2021. PMID: 33588426 Free PMC article.

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