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Comment
. 2021 Apr 12;39(4):463-465.
doi: 10.1016/j.ccell.2021.03.005.

A large-scale snapshot of intratumor heterogeneity in human cancer

Young Seok Ju  1
Affiliations
Free article
Comment

A large-scale snapshot of intratumor heterogeneity in human cancer

Young Seok Ju. Cancer Cell. .
Free article

Abstract

Using sophisticated statistical analyses on population-scale cancer whole-genome sequences, a new study published in Cell characterizes the genomic architecture of intratumor heterogeneity (ITH). It results in an unprecedented snapshot of subclones in about 30 cancer types, generating a wealth of insight into the underlying mutational events, processes, and their selection.

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Conflict of interest statement

Declaration of interests Y.S.J is the co-founder and CEO of GENOME INSIGHT Inc.

Comment on

  • Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes.
    Dentro SC, Leshchiner I, Haase K, Tarabichi M, Wintersinger J, Deshwar AG, Yu K, Rubanova Y, Macintyre G, Demeulemeester J, Vázquez-García I, Kleinheinz K, Livitz DG, Malikic S, Donmez N, Sengupta S, Anur P, Jolly C, Cmero M, Rosebrock D, Schumacher SE, Fan Y, Fittall M, Drews RM, Yao X, Watkins TBK, Lee J, Schlesner M, Zhu H, Adams DJ, McGranahan N, Swanton C, Getz G, Boutros PC, Imielinski M, Beroukhim R, Sahinalp SC, Ji Y, Peifer M, Martincorena I, Markowetz F, Mustonen V, Yuan K, Gerstung M, Spellman PT, Wang W, Morris QD, Wedge DC, Van Loo P; PCAWG Evolution and Heterogeneity Working Group and the PCAWG Consortium. Dentro SC, et al. Cell. 2021 Apr 15;184(8):2239-2254.e39. doi: 10.1016/j.cell.2021.03.009. Epub 2021 Apr 7. Cell. 2021. PMID: 33831375 Free PMC article.

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