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. 1977 Dec;18(3):654-9.
doi: 10.1128/iai.18.3.654-659.1977.

Induction of cell-mediated immunity to Mycobacterium lepraemurium in susceptible mice

M J Lefford, P J Patel, L W Poulter, G B Mackaness

Induction of cell-mediated immunity to Mycobacterium lepraemurium in susceptible mice

M J Lefford et al. Infect Immun. 1977 Dec.

Abstract

A mouse strain (CB6) that is highly susceptible to Mycobacterium lepraemurium was infected with 10(8) bacilli into the hind footpad. These mice developed cell-mediated immunity to M. lepraemurium, as expressed by the development of a granulomatous lesion at the site of inoculation in normal but not in T-lymphocyte-depleted mice, a proliferative response in the paracortical zone of the draining lymph node, delayed-type hypersensitivity to a sonic extract of M. lepraemurium, and immunopotentiation of the delayed hypersensitivity response to sheep erythrocytes. Resistance to a second challenge infection with M. lepraemurium was not demonstrated.

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