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. 2021 Apr 13;19(1):4.
doi: 10.1186/s12948-021-00143-y.

H2-antagonist in IgE-mediated type I hypersensitivity reactions: what literature says so far?

Matteo Borro  1   2   3 , Simone Negrini  4 , Andrew Long  5 , Sharon Chinthrajah  5 , Giuseppe Murdaca  4
Affiliations

H2-antagonist in IgE-mediated type I hypersensitivity reactions: what literature says so far?

Matteo Borro et al. Clin Mol Allergy. .

Abstract

Histamine is a monoamine synthesized from the amino acid histidine that is well-known for its role in IgE-mediated anaphylaxis but has shown pleiotropic effects on the immune system, especially in order to promote inflammatory responses. H1-receptor antagonist are common drugs used in mild/moderate allergic reactions whereas H2-receptor antagonist are commonly administered in gastric ulcer but showed some properties in allergy too. The EAACI guidelines for diagnosis and treatment of anaphylactic reactions recommend their use as third-line therapy in adjunct to H1-antagonists. The purpose of this article is to produce a complete summary of findings and evidence known so far about the usefulness of H2-receptor antagonist in allergic reactons.

Keywords: Allergy; H2-receptor antagonist; Histamine; Type-I hypersensitivity reaction.

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Conflict of interest statement

The authors declare that they have no competing interests.

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