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. 2021 Apr 13;18(1):41.
doi: 10.1186/s12954-021-00488-2.

Evaluation of functional status among patients undergoing maintenance treatments for opioid use disorders

Juan J Ruíz Ruíz  1 , José M Martinez Delgado  2 , Nuria García-Marchena  3   4 ; ANDOPIO Study Group
Collaborators, Affiliations

Evaluation of functional status among patients undergoing maintenance treatments for opioid use disorders

Juan J Ruíz Ruíz et al. Harm Reduct J. .

Abstract

Background: Methadone and buprenorphine are the most prevalent types of opioid maintenance programs in Andalusia. The main objective is comparing the functional status of patients with pharmacological opioid maintenance treatments according to different socio-demographic characteristic, health and disabilities domains and sexual difficulties.

Methods: A total of 593 patients from the Andalusia community, 329 were undergoing methadone treatment and 264 were undergoing buprenorphine treatment. The patients were interviewed by socio-demographic and opioid-related variables, assessed by functioning, disability and health domains (WHODAS 2.0.) and for sexual problems (PRSexDQ-SALSEX).

Results: We found significant differences in the socio-demographic and the opioid-related variables as the onset of opioid use, being on previous maintenance programs, opioid intravenous use, the length of previous maintenance programs, polydrug use and elevated seroprevalence rates (HCV and HIV) between the methadone group and the buprenorphine group. Regarding health and disability domains there were differences in the Understanding and communication domain, Getting around domain, Participation in society domain and in the WHODAS 2.0. simple and complex score, favoring buprenorphine-treated patients. The methadone group referred elevated sexual impairments compared with the buprenorphine group. Opioid-related variables as seroprevalence rates, other previous lifetime maintenance program, the daily opioid dosage and the daily alcohol use are the most discriminative variables between both groups. Participation in society variables and sexual problems were the most important clinical variables in distinguishing the methadone group from the buprenorphine group regarding their functional status.

Conclusions: The methadone group showed higher prevalence in opioid dependence-related variables, elevated disabilities in participation in society activities and sexual problems compared with the buprenorphine group. This study shows the importance of carry out a functional evaluation in the healthcare follow-up, especially in those areas related with social activity and with sexual problems.

Keywords: Buprenorphine; Functional status; Methadone; Opioid use disorders; Sexual dysfunction.

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Conflict of interest statement

The authors declare that they have no competing interests.

References

    1. Degenhardt L, et al. The global epidemiology and burden of opioid dependence: results from the Global Burden of Disease 2010 study. Addiction. 2014;109:1320–1333. doi: 10.1111/add.12551. - DOI - PubMed
    1. EMCDDA . European drug report 2019: trends and developments. Luxembourg: Publications Office of the European Union; 2019.
    1. EMCDDA. European Monitoring Centre for Drugs and Drug Addiction. Spain. Country Drug Report 2017. 2017.
    1. CªIyPS, Consejería de Igualdad y Políticas Sociales. Indicador admisiones a tratamiento por abuso o dependencia a sustancias o por adicciones comportamentales en Andalucía. 2017. Junta de Andalucía: Agencia de Servicios Sociales y Dependencia de Andalucía; 2018.
    1. CªIyPS, Consejería de Igualdad y Políticas Sociales. Área de Drogodependencias y Adicciones. Memoria 2016. Junta de Andalucía: Secretaría General de Servicios Sociales; 2016.

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