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Comment
. 2021 Jun 1;32(6):1537.
doi: 10.1681/ASN.2021020204. Epub 2021 Apr 13.

On the Increased Event Rate of Urinary Tract Infection and Pneumonia in CKD Patients Treated with Roxadustat for Anemia

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Comment

On the Increased Event Rate of Urinary Tract Infection and Pneumonia in CKD Patients Treated with Roxadustat for Anemia

Theodoros Eleftheriadis et al. J Am Soc Nephrol. .
No abstract available

Keywords: T cell; immune response; infection; roxadustat anemia.

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  • Authors' Reply.
    Fishbane S, El-Shahawy MA, Van BP, Little DJ. Fishbane S, et al. J Am Soc Nephrol. 2021 Jun 1;32(6):1537-1538. doi: 10.1681/ASN.2021030334. Epub 2021 Apr 13. J Am Soc Nephrol. 2021. PMID: 33849916 Free PMC article. No abstract available.

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References

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    1. Chen N, Hao C, Liu B-C, Lin H, Wang C, Xing C, et al. .: Roxadustat treatment for anemia in patients undergoing long-term dialysis. N Engl J Med 381: 1011–1022, 2019. - PubMed
    1. Akizawa T, Iwasaki M, Yamaguchi Y, Majikawa Y, Reusch M: Phase 3, randomized, double-blind, active-comparator (darbepoetin alfa) study of oral roxadustat in CKD patients with anemia on hemodialysis in Japan. J Am Soc Nephrol 31: 1628–1639, 2020. - PMC - PubMed
    1. Tao J-H, Barbi J, Pan F: Hypoxia-inducible factors in T lymphocyte differentiation and function. A review in the theme: Cellular responses to hypoxia. Am J Physiol Cell Physiol 309: C580–C589, 2015. - PMC - PubMed
    1. Eleftheriadis T, Pissas G, Mavropoulos A, Nikolaou E, Filippidis G, Liakopoulos V, et al. .: In mixed lymphocyte reaction, the hypoxia-inducible factor prolyl-hydroxylase inhibitor roxadustat suppresses cellular and humoral alloimmunity. Arch Immunol Ther Exp (Warzs) 68: 31, 2020. - PubMed

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