Expert consensus of the Chinese Association for the Study of Pain on ion channel drugs for neuropathic pain

doi:10.12998/wjcc.v9.i9.2100

Review

. 2021 Mar 26;9(9):2100-2109.

doi: 10.12998/wjcc.v9.i9.2100.

Expert consensus of the Chinese Association for the Study of Pain on ion channel drugs for neuropathic pain

Hong Xiao¹, Ke Ma², Dong Huang³, Xian-Guo Liu⁴, Tang-Hua Liu⁵, Qing Liu⁶, Guang-Zhao Liu⁷, Tao Song⁸, Wei Tao⁹, Da-Sheng Wu¹⁰, Yun-Xia Wang¹¹, Xiao-Qiu Yang¹², Xiao-Mei Zhang¹³, Hui Liu¹⁴, Yan-Qing Liu¹⁵

Affiliations

¹ Department of Algology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.
² Department of Algology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.
³ Department of Algology, The Third Xiangya Hospital of Central South University, Changsha 410013, Hunan Province, China.
⁴ Department of Physiology and Pain Research Center, Sun Yat-Sen University, Guangzhou 510080, Guangdong Province, China.
⁵ Department of Algology, The Third People's Hospital of Yibin, Yibin 644000, Sichuan Province, China.
⁶ Department of Algology, The Affiliated T.C.M Hospital of Southwest Medical University, Luzhou 646000, Sichuan Province, China.
⁷ Department of Algology, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei Province, China.
⁸ Department of Algology, The First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China.
⁹ Department of Neurosurgery, Shenzhen University General Hospital, Shenzhen 518055, Guangdong Province, China.
¹⁰ Department of Algology, The People's Hospital of Jilin Province, Changchun 130021, Jilin Province, China.
¹¹ Department of Algology, Hubei Third People's Hospital of Jianghan University, Wuhan 430033, Hubei Province, China.
¹² Department of Algology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
¹³ Department of Algology, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan Province, China.
¹⁴ Department of Algology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China. 18980601547@qq.com.
¹⁵ Department of Algology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.

PMID: 33850929
PMCID: PMC8017507
DOI: 10.12998/wjcc.v9.i9.2100

Review

Expert consensus of the Chinese Association for the Study of Pain on ion channel drugs for neuropathic pain

Hong Xiao et al. World J Clin Cases. 2021.

. 2021 Mar 26;9(9):2100-2109.

doi: 10.12998/wjcc.v9.i9.2100.

Authors

Affiliations

¹ Department of Algology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.
² Department of Algology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.
³ Department of Algology, The Third Xiangya Hospital of Central South University, Changsha 410013, Hunan Province, China.
⁴ Department of Physiology and Pain Research Center, Sun Yat-Sen University, Guangzhou 510080, Guangdong Province, China.
⁵ Department of Algology, The Third People's Hospital of Yibin, Yibin 644000, Sichuan Province, China.
⁶ Department of Algology, The Affiliated T.C.M Hospital of Southwest Medical University, Luzhou 646000, Sichuan Province, China.
⁷ Department of Algology, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei Province, China.
⁸ Department of Algology, The First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China.
⁹ Department of Neurosurgery, Shenzhen University General Hospital, Shenzhen 518055, Guangdong Province, China.
¹⁰ Department of Algology, The People's Hospital of Jilin Province, Changchun 130021, Jilin Province, China.
¹¹ Department of Algology, Hubei Third People's Hospital of Jianghan University, Wuhan 430033, Hubei Province, China.
¹² Department of Algology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
¹³ Department of Algology, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan Province, China.
¹⁴ Department of Algology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China. 18980601547@qq.com.
¹⁵ Department of Algology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.

PMID: 33850929
PMCID: PMC8017507
DOI: 10.12998/wjcc.v9.i9.2100

Abstract

Neuropathic pain (NPP) is a kind of pain caused by disease or damage impacting the somatosensory system. Ion channel drugs are the main treatment for NPP; however, their irregular usage leads to unsatisfactory pain relief. To regulate the treatment of NPP with ion channel drugs in clinical practice, the Chinese Association for the Study of Pain organized first-line pain management experts from China to write an expert consensus as the reference for the use of ion channels drugs . Here, we reviewed the mechanism and characteristics of sodium and calcium channel drugs, and developed recommendations for the therapeutic principles and clinical practice for carbamazepine, oxcarbazepine, lidocaine, bulleyaconitine A, pregabalin, and gabapentin. We hope this guideline provides guidance to clinicians and patients on the use of ion channel drugs for the management of NPP.

Keywords: Bulleyaconitine A; Carbamazepine; Expert consensus; Gabapentin; Guideline; Ion channel drug; Lidocaine; Neuropathic pain; Oxcarbazepine; Pregabalin.

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Conflict of interest statement

Conflict-of-interest statement: The authors disclosure no conflict of interest.

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References

1. Jensen TS, Baron R, Haanpää M, Kalso E, Loeser JD, Rice ASC, Treede RD. A new definition of neuropathic pain. Pain. 2011;152:2204–2205. - PubMed
1. van Hecke O, Austin SK, Khan RA, Smith BH, Torrance N. Neuropathic pain in the general population: a systematic review of epidemiological studies. Pain. 2014;155:654–662. - PubMed
1. Gierthmühlen J, Baron R. Neuropathic Pain. Semin Neurol. 2016;36:462–468. - PubMed
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1. Eisenberg E, River Y, Shifrin A, Krivoy N. Antiepileptic drugs in the treatment of neuropathic pain. Drugs. 2007;67:1265–1289. - PubMed

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[1] Jensen TS, Baron R, Haanpää M, Kalso E, Loeser JD, Rice ASC, Treede RD. A new definition of neuropathic pain. Pain. 2011;152:2204–2205. - PubMed

[2] Jensen TS, Baron R, Haanpää M, Kalso E, Loeser JD, Rice ASC, Treede RD. A new definition of neuropathic pain. Pain. 2011;152:2204–2205. - PubMed

[3] van Hecke O, Austin SK, Khan RA, Smith BH, Torrance N. Neuropathic pain in the general population: a systematic review of epidemiological studies. Pain. 2014;155:654–662. - PubMed

[4] van Hecke O, Austin SK, Khan RA, Smith BH, Torrance N. Neuropathic pain in the general population: a systematic review of epidemiological studies. Pain. 2014;155:654–662. - PubMed

[5] Gierthmühlen J, Baron R. Neuropathic Pain. Semin Neurol. 2016;36:462–468. - PubMed

[6] Gierthmühlen J, Baron R. Neuropathic Pain. Semin Neurol. 2016;36:462–468. - PubMed

[7] Rivara M, Zuliani V. Novel sodium channel antagonists in the treatment of neuropathic pain. Expert Opin Investig Drugs. 2016;25:215–226. - PubMed

[8] Rivara M, Zuliani V. Novel sodium channel antagonists in the treatment of neuropathic pain. Expert Opin Investig Drugs. 2016;25:215–226. - PubMed

[9] Eisenberg E, River Y, Shifrin A, Krivoy N. Antiepileptic drugs in the treatment of neuropathic pain. Drugs. 2007;67:1265–1289. - PubMed

[10] Eisenberg E, River Y, Shifrin A, Krivoy N. Antiepileptic drugs in the treatment of neuropathic pain. Drugs. 2007;67:1265–1289. - PubMed

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Expert consensus of the Chinese Association for the Study of Pain on ion channel drugs for neuropathic pain

Affiliations

Expert consensus of the Chinese Association for the Study of Pain on ion channel drugs for neuropathic pain

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