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Case Reports
. 2021 Jun;6(6):1732-1737.
doi: 10.1016/j.ekir.2021.03.897. Epub 2021 Apr 8.

Kidney Thrombotic Microangiopathy After COVID-19 Associated With C3 Gene Mutation

Olivier Mat  1 , Lidia Ghisdal  1 , Annick Massart  2 , Selda Aydin  3 , Ahmed Goubella  1 , Niko Blankoff  4 , Fabrice Gankam  1 , Frédéric Debelle  1 , Quentin Mat  5
Affiliations
Case Reports

Kidney Thrombotic Microangiopathy After COVID-19 Associated With C3 Gene Mutation

Olivier Mat et al. Kidney Int Rep. 2021 Jun.
No abstract available

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Figures

Figure 1
Figure 1
Renal biopsy findings (original magnification ×40). The glomerular capillary lumina were narrowed. Diffuse endocapillary proliferative changes were observed with endothelial swelling (black arrows) and duplication of glomerular basement membrane (red arrows) (a, periodic acid–Schiff staining). The foci of acute interstitial nephritis were characterized by edema (black star) and few mononuclear inflammatory cells (black arrows) (b, Masson trichrome staining). Some small arteries have obliterated lumina (c, hematoxylin eosin staining, black arrows) and mucoid thickening of the intima (d, Masson trichrome staining).
Figure 2
Figure 2
(a) Evolution of the biochemical parameters (i.e., platelets, lactate dehydrogenase [LDH], hemoglobin [Hb], and schistocytes) after admission and during therapies (i.e., therapeutic plasma exchange [TPE], hemodialysis, methylprednisolone, and initiation of eculizumab). (b) The trend of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) IgG antibodies during TPE.
See this image and copyright information in PMC

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