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. 2021 Aug;93(8):5110-5117.
doi: 10.1002/jmv.27020. Epub 2021 Apr 23.

Respective prevalence of high-risk HPVgenotypes in cervical neoplasia in Senegal

Halimatou Diop-Ndiaye  1 , Xavier Sastre-Garau  2 , Aboubacry Drame  1 , Birama Dembele  3 , Nafissatou N Ba  4 , Oumy Diop-Diongue  1 , Madeleine Mbow  3 , Mba E B Diakhaby  5 , Gisele Woto-Gaye  4 , Coumba Toure Kane  5 , Mamadou Diop  3
Affiliations

Respective prevalence of high-risk HPVgenotypes in cervical neoplasia in Senegal

Halimatou Diop-Ndiaye et al. J Med Virol. 2021 Aug.

Abstract

Objectives: With the perspective of prophylactic vaccination against high-risk human papillomavirus (HPV), we analyzed the viral epidemiology of cervical neoplasia in Senegal.

Methods: All patients were treated at the Institut Joliot Curie du Cancer in Dakar. HPV genotypes were characterized using a real-time polymerase chain reaction-based approach and sequencing.

Results: Histologically, there were 224 invasive carcinomas, 17 high-grade intraepithelial neoplasia (CIN), and five undetermined histologies. Molecular analysis was conclusive in 241 cases. HPV DNA was found in 207/241 (85.9%) cases while 34/241 (14.1%) remained HPV negative. There was one single genotype in 127/207 (61.4%) cases and several in 80/207 (38.6%) corresponding to 308 genotypes identified. Viral genotyping found HPV16 in 175 (56.8%) cases, HPV18 in 45 (14.6%), HPV45 in 40 (13.0%), HPV58 in 35 (11.4%), HPV33 in 6 (2.0%), HPV35 in 3 (1.0%), HPV31 in 2 (0.6%), HPV39 and HPV56 in one (0.3% each).

Conclusion: Our analysis showed that 98.4% of the HPV-positive cases were associated with viral genotypes covered by the 9-valent HPV vaccine. However, 14.1% of cases remained HPV negative. Therefore, prophylactic vaccination using a 9-valent vaccine should dramatically reduce the incidence of HPV-associated neoplasia but the detection and treatment of CIN remain necessary for the optimal prevention of cervical cancer.

Keywords: HPV negative cervical cancers; cervical neoplasia; high-risk HPV.

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References

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