Primer malignant giant cell tumour of kidney: a case report

Abstract

Osteoclast-like giant cell tumours of the kidney are extremely rare and usually accompanied by a conventional urothelial neoplasm such as papillary, transitional renal cell, or sarcomatoid carcinoma. Although they have morphological features similar to those of the giant cell tumours in the skeletal system, their counterparts in the urinary system show highly malignant features. Our case is the third primer malignant giant cell tumour of the kidney in the literature. The patient was a 50-year-old male and underwent nephroureterectomy for a mass of 18×14×13cm in his left kidney. However, the patient died in the second month postoperatively as a result of local recurrences and multiple distant metastases. The general condition of the patient deteriorated progressively; hence, he could not have any adjuvant therapy. Having more information about the pathological and clinical findings of these exceedingly rare tumours can help inform treatment steps.

Keywords: Giant cell tumour; Kidney; Malign; Osteoclast-like tumour.

Figure 1

CT images of the tumour in the left kidney. (a) Coronal section, (b) axial section. CT = computed tomography.

Figure 2

Osteoclast-like giant cells in the stroma characterised by spindle cells, atypical stromal cells and numerous mitotic figures (magnification 40×)

Figure 3

Lymphovascular invasion (magnification 100×)

Figure 4

Focal necrotic areas (magnification 100×)