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Case Reports
. 2021 Apr 14;21(1):152.
doi: 10.1186/s12905-021-01284-7.

Lung Adenocarcinoma with Metachronous Ovarian Metastasis: a long survival case report

Shuyang Yao  1 , Leiming Wang  2 , Xiaoru Tian  1 , Yi Zhang  3
Affiliations
Case Reports

Lung Adenocarcinoma with Metachronous Ovarian Metastasis: a long survival case report

Shuyang Yao et al. BMC Womens Health. .

Abstract

Background: Lung adenocarcinoma which invades ovaries is very rare. However, with the increase of long-survival female lung cancer, more patients will suffer ovarian metastasis. On grounds of the paucity of reported cases, the clinicopathological features and treatment strategies remain unknown.

Case presentation: This patient was stage IV lung adenocarcinoma at first diagnosis. Following multiple-line systemic treatments, she experienced extensive pelvic metastasis. After debulking surgery and reevaluation about the drive genes, she was administered by targeted therapy. Up to now, the patient has shown no evidence of progression for 8 years after the initial diagnosis of primary lung cancer and 46 months after her ovarian metastasis.

Conclusion: The comprehensive treatment modality for the bilateral ovarian metastasis is effective in clinical course.

Keywords: Case report; Debulking surgery; Lung adenocarcinoma; Ovarian metastasis; Targeted therapy.

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Conflict of interest statement

The authors declare that there are no conflicts of interest.

Figures

Fig. 1
Fig. 1
In 2006, from debulking surgery, tumor cells are arranged into glandular tubular and papillary structures with apical snouts and huge, hyperchromatic nuclei. a H&E, ×100; b H&E, ×400; In 2002, from pleural biopsy, tumor cells are arranged into glandular tubular and papillary structures with apical snouts and huge, hyperchromatic nuclei. a H&E, ×100; b H&E, ×400
Fig. 2
Fig. 2
In tissue from the ovarian debulking surgery, a tumor cells are immunopositive for TTF1. IHC, ×400; b Tumor cells are immunopositive for NapsinA. IHC, ×400; c Tumor cells are immunopositive for CK7. IHC, ×400
See this image and copyright information in PMC

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