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Meta-Analysis
. 2021 Apr 14;19(1):119.
doi: 10.1186/s12957-021-02230-5.

Effect of endoscopic resection on short-term surgical outcomes of subsequent laparoscopic gastrectomy: a meta-analysis

Dong Peng  1 , Yu-Xi Cheng  1 , Gang Liao  2
Affiliations
Meta-Analysis

Effect of endoscopic resection on short-term surgical outcomes of subsequent laparoscopic gastrectomy: a meta-analysis

Dong Peng et al. World J Surg Oncol. .

Abstract

Background: Endoscopic resection (ER) might affect subsequent laparoscopic gastrectomy (LG) because of the electrical coagulation, but the effect remains controversial. The purpose of this meta-analysis was to analyze the effect of ER on the short-term surgical outcomes of subsequent LG.

Materials and methods: The PubMed, EMBASE, and Cochrane Library databases were searched to find eligible studies published from inception to March 21, 2021. Short-term surgical outcomes were compared between the ER-LG group and the LG-only group. The registration ID of this current meta-analysis on PROSPERO is CRD42021238031.

Results: Nine studies involving 3611 patients were included in this meta-analysis. The LG-only group had a higher T stage (T1-T2: OR=2.42, 95% CI=1.09 to 5.34, P=0.03; T3-T4: OR=0.41, 95% CI=0.19 to 0.91, P=0.03) than the ER-LG group. The ER-LG group showed a shorter operation time than the LG-only group (MD=-5.98, 95% CI=-10.99 to -0.97, P=0.02). However, no difference was found in operation time after subgroup analysis of propensity score matching studies. No significant difference was found in intraoperative blood loss, time to first oral feeding, or postoperative hospital stay between the ER-LG group and the LG-only group. And no significance was found in overall complications (OR=1.16, 95% CI=0.89 to 1.50, P=0.27), complications of grade ≥ II (OR=1.11, 95% CI=0.71 to 1.73, P=0.64), complications of grade ≥ III b (OR=1.47, 95% CI=0.49 to 4.43, P=0.49) between the ER-LG group and the LG-only group.

Conclusions: ER did not affect subsequent LG in terms of short-term outcomes, and the ER-LG group might have a shorter operation time than the LG-only group.

Keywords: Endoscopic resection; Gastric cancer; Laparoscopic gastrectomy; Meta-analysis.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Flowchart of study selection
Fig. 2
Fig. 2
Forest plot of the operation time. 95% CI, 95% confidence interval; ER, endoscopic resection; LG, laparoscopic gastrectomy
Fig. 3
Fig. 3
Forest plot showing postoperative complications. (a) Overall postoperative complications; (b) complications of grade ≥ II; (c) complications of grade ≥ III b. 95% CI, 95% confidence interval; ER, endoscopic resection; LG, laparoscopic gastrectomy
Fig. 4
Fig. 4
Funnel plot of overall postoperative complications. SE, standard error; OR, odds ratio
See this image and copyright information in PMC

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References

    1. Kamangar F, Dores GM, Anderson WF. Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world. J. Clin. Oncol. 2006;24(14):2137–50. 10.1200/JCO.2005.05.2308. - PubMed
    1. Ferlay J, Steliarova FE, Lortet TJ, et al. Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012. Eur. J. Cancer. 2013;49(6):1374–403. 10.1016/j.ejca.2012.12.027. - PubMed
    1. Saragoni L, Morgagni P, Gardini A, Marfisi C, Vittimberga G, Garcea D, et al. Early gastric cancer: diagnosis, staging, and clinical impact. Evaluation of 530 patients. New elements for an updated definition and classification. Gastric Cancer. 2013;16(4):549–54. 10.1007/s10120-013-0233-2. - PubMed
    1. Nie RC, Yuan SQ, Li YF, Chen S, Chen YM, Chen XJ, et al. Additional gastrectomy in early-stage gastric cancer after non-curative endoscopic resection: a meta-analysis. Gastroenterol Rep (Oxf). 2019;7(2):91–7. 10.1093/gastro/goz007. - PMC - PubMed
    1. Tsujitani S, Oka S, Saito H, Kondo A, Ikeguchi M, Maeta M, et al. Less invasive surgery for early gastric cancer based on the low probability of lymph node metastasis. Surgery. 1999;125(2):148–54. 10.1016/S0039-6060(99)70258-8. - PubMed

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