Correction: ZHX2 drives cell growth and migration via activating MEK/ERK signal and induces Sunitinib resistance by regulating the autophagy in clear cell Renal Cell Carcinoma

Liangsong Zhu^#¹, Rong Ding^#², Hao Yan¹, Jin Zhang³, Zongming Lin⁴

Affiliations

¹ Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China.
² Department of Obstetrics and Gynecology, International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
³ Department of Urology, Ren Ji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China. med-zhangjin@vip.sina.com.
⁴ Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China. lin.zongming@zs-hospital.sh.cn.

^# Contributed equally.

PMID: 33854032
PMCID: PMC8046752
DOI: 10.1038/s41419-021-03678-9

Published Erratum

Correction: ZHX2 drives cell growth and migration via activating MEK/ERK signal and induces Sunitinib resistance by regulating the autophagy in clear cell Renal Cell Carcinoma

Liangsong Zhu et al. Cell Death Dis. 2021.

. 2021 Apr 14;12(4):399.

doi: 10.1038/s41419-021-03678-9.

Authors

Liangsong Zhu^#¹, Rong Ding^#², Hao Yan¹, Jin Zhang³, Zongming Lin⁴

Affiliations

¹ Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China.
² Department of Obstetrics and Gynecology, International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
³ Department of Urology, Ren Ji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China. med-zhangjin@vip.sina.com.
⁴ Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China. lin.zongming@zs-hospital.sh.cn.

^# Contributed equally.

PMID: 33854032
PMCID: PMC8046752
DOI: 10.1038/s41419-021-03678-9

No abstract available

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Figures

**Fig. 5. ZHX2 promotes ccRCC growth by transcriptional activates the MEK1/ERK1/2 signaling pathway.**
a The heat map of total differentialgenes in 786-O cells with LV-ZHX2 and negative control. b KEGG enrichment analysis was performed to explore the related pathways according tothe RNA-seq data. c, d The mRNA expressions of related downstream genes in MAPK/ERK1/2 pathway in 786-O/LV-ZHX2 cells. e, f The ChIP-qpcr andluciferase assays were showed ZHX2 could direct bind to the promoter of MAP2K1 in 786-O cells. g The predicted binding motif of ZHX2 in genome. h The western blot assay was used to test the protein level of MEK-ERK signal in reprogrammed 786-O and CAKI-1 cells. All experiments wererepeated double times. *p < 0.05, **p < 0.01, and ***p < 0.001.

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Erratum for

ZHX2 drives cell growth and migration via activating MEK/ERK signal and induces Sunitinib resistance by regulating the autophagy in clear cell Renal Cell Carcinoma.
Zhu L, Ding R, Yan H, Zhang J, Lin Z. Zhu L, et al. Cell Death Dis. 2020 May 7;11(5):337. doi: 10.1038/s41419-020-2541-x. Cell Death Dis. 2020. PMID: 32382017 Free PMC article.

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Correction: ZHX2 drives cell growth and migration via activating MEK/ERK signal and induces Sunitinib resistance by regulating the autophagy in clear cell Renal Cell Carcinoma

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Correction: ZHX2 drives cell growth and migration via activating MEK/ERK signal and induces Sunitinib resistance by regulating the autophagy in clear cell Renal Cell Carcinoma

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