Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Oct;479(4):765-772.
doi: 10.1007/s00428-021-03099-1. Epub 2021 Apr 14.

Tertiary lymphoid structures in epithelioid malignant peritoneal mesothelioma are associated with neoadjuvant chemotherapy, but not with prognosis

Nazim Benzerdjeb  1 , Peggy Dartigues  2 , Vahan Kepenekian  3 , Séverine Valmary-Degano  4 , Eliane Mery  5 , Gerlinde Avérous  6 , Anne Chevallier  7 , Marie-Hélène Laverriere  4 , Irène Villa  2 , Olivier Harou  8 , Françoise Galateau Sallé  9 , Laurent Villeneuve  10 , Olivier Glehen  3 , Sylvie Isaac  8 , Juliette Hommell-Fontaine  8 , Frédéric Bibeau  11 ; RENAPE Network
Collaborators, Affiliations

Tertiary lymphoid structures in epithelioid malignant peritoneal mesothelioma are associated with neoadjuvant chemotherapy, but not with prognosis

Nazim Benzerdjeb et al. Virchows Arch. 2021 Oct.

Abstract

Epithelioid mesothelioma is the most prevalent subtype of diffuse malignant peritoneal mesothelioma. The relationship between a strong adaptive immune response and a better prognosis in malignant solid tumors is widely known. Due to the low incidence of epithelioid malignant peritoneal mesothelioma (EMPM), very little is known about their immune micro-environment. We encountered several cases of tertiary lymphoid structures in EMPM in a previous study and aimed to investigate in the same series the prevalence, clinicopathological features, and the prognostic impact associated with tertiary lymphoid structures in EMPM (TLS-EMPM). Cases of EMPM, from 1995 to 2018, were retrieved from 7 French institutions from the RENAPE Network. The predictions in terms of overall survival (OS) and progression-free survival (PFS) of TLS-EMPM were analyzed. We report 52 cases of TLS-EMPM among a series of 138 cases of EMPM. TLS-EMPM was significantly associated with neoadjuvant chemotherapy, and was not a prognostic indicator for OS (p = 0.652) and PFS (p = 0.804) in our series. TLS is a component of the host immune response to EMPM significantly associated with neoadjuvant chemotherapy, but was not a predictor of prognosis for overall and progression-free survivals in this series. These findings provide another possible etiology for tertiary lymphoid structures.

Keywords: Biomarker; Malignant epithelioid peritoneal mesothelioma; Mesothelioma; Tertiary lymphoid structures.

PubMed Disclaimer

References

    1. Glehen O. Mésothéliome péritonéal malin. In: Orphanet. https://www.orpha.net/consor/cgi-bin/OC_Exp.php?Expert=168811&lng=FR
    1. Husain A, Colby T, Ordóñez N et al (2018) Guidelines for pathologic diagnosis of malignant mesothelioma 2017 update of the consensus statement from the International Mesothelioma Interest Group. Arch Pathol Lab Med 142:89–108. https://doi.org/10.5858/arpa.2017-0124-RA - DOI - PubMed
    1. Yan T, Deraco M, Baratti D et al (2009) Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for malignant peritoneal mesothelioma: multi-institutional experience. J Clin Oncol 27:6237–6242. https://doi.org/10.1200/JCO.2009.23.9640 - DOI - PubMed
    1. Fridman W, Pagès F, Sautès-Fridman C, Galon J (2012) The immune contexture in human tumours: impact on clinical outcome. Nat Rev Cancer 12:298–306. https://doi.org/10.1038/nrc3245 - DOI - PubMed
    1. Maoz A, Dennis M, Greenson J (2019) The Crohn’s-like lymphoid reaction to colorectal cancer-tertiary lymphoid structures with immunologic and potentially therapeutic relevance in colorectal cancer. Front Immunol 10:1884. https://doi.org/10.3389/fimmu.2019.01884 - DOI - PubMed - PMC

MeSH terms

LinkOut - more resources