Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Aug;37(8):1021-1029.
doi: 10.1007/s00383-021-04900-7. Epub 2021 Apr 14.

Surgical management of unilateral oophorectomy for ovarian tissue cryopreservation in high-risk children and adolescents with varied backgrounds

Seido Takae  1 , Shigeyuki Furuta  2 , Dai Keino  3   4 , Eriko Shiraishi  1 , Yuriko Iwahata  1 , Kei Oyama  2 , Hideyuki Iwahata  1 , Yuri Nishiya  2 , Kohei Kawaguchi  2 , Juma Obayashi  2 , Kunihide Tanaka  2 , Shino Sawada  1 , Yuki Suzuki  1 , Yodo Sugishita  1 , Imari Deura  1 , Yuki Horage  1 , Hideki Nagae  2 , Haruhiro Kondo  1 , Miki Sakamoto  5 , Tetsuya Mori  4 , Hiroaki Kitagawa  2 , Nao Suzuki  6
Affiliations

Surgical management of unilateral oophorectomy for ovarian tissue cryopreservation in high-risk children and adolescents with varied backgrounds

Seido Takae et al. Pediatr Surg Int. 2021 Aug.

Abstract

Purpose: Fertility preservation (FP) for children is still challenging due to an information gap. In particular, there is little information about the surgical aspects of ovarian tissue cryopreservation (OTC) for children. In the present study, the appropriateness of preoperative management and the criteria of our cases were investigated with the aim of establishing a safe OTC procedure.

Methods: A total of 25 girls who underwent OTC from November 2015 through May 2020 were retrospectively analyzed with IRB approval.

Results: The median age of the patients was 13 (1-17) years. The medical indications were varied (e.g., leukemia, lymphoma, brain tumor), and included rare diseases. Seventeen cases (68%) underwent OTC during chemotherapy or radiotherapy, and 21 (84%) had comorbidities. All cases underwent ovarian tissue retrieval (OTR) with laparoscopy, and the median operating time was 64 (36-97) min, with little bleeding. Although two had complications, all patients started treatment on schedule. The median WBC and CRP increases a day after OTR were 0 (- 4400 to + 5200)/µl and 0.21 (- 0.2 to 0.87) mg/dl, respectively, with no complications.

Conclusion: As long as the preoperative criteria are met, OTC could be possible even for children with a severe blood condition. In such cases, the degrees of the WBC and CRP elevations are useful to assess surgical infection.

Keywords: Child cancer patient; Fertility preservation; Oophorectomy; Ovarian tissue cryopreservation; Surgical management.

PubMed Disclaimer

References

    1. Lehmann V, Keim MC, Nahata L et al (2017) Fertility-related knowledge and reproductive goals in childhood cancer survivors: short communication. Hum Reprod 32:2250–2253. https://doi.org/10.1093/humrep/dex297 - DOI - PubMed
    1. Practice Committee of the American Society for Reproductive Medicine (2019) Fertility preservation in patients undergoing gonadotoxic therapy or gonadectomy: a committee opinion. Fertil Steril 112:1022–1033. https://doi.org/10.1016/j.fertnstert.2019.09.013 - DOI
    1. Oktay K, Harvey BE, Partridge AH et al (2018) Fertility preservation in patients with cancer: ASCO Cl. J Clin Oncol 36:1994–2001. https://doi.org/10.1200/JCO.2018.78.1914 - DOI - PubMed
    1. Loren AW, Mangu PB, Beck LN et al (2013) Fertility preservation for patients with cancer: American Society of Clinical Oncology clinical practice guideline update. J Clin Oncol 31:2500–2510. https://doi.org/10.1200/JCO.2013.49.2678 - DOI - PubMed - PMC
    1. Donnez J, Dolmans MM (2017) Fertility preservation in women. N Engl J Med 377:1657–1665. https://doi.org/10.1056/NEJMra1614676 - DOI - PubMed

LinkOut - more resources