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Comment
. 2021 Apr 15;137(15):1992-1993.
doi: 10.1182/blood.2020010035.

Familial patterns of hematologic precursors

Ola Landgren  1 , Francesco Maura  1
Affiliations
Comment

Familial patterns of hematologic precursors

Ola Landgren et al. Blood. .

Abstract

In this issue of Blood, Slager et al report novel results from a large familial screening study including 1045 relatives from 310 families that include a patient with chronic lymphocytic leukemia (CLL).

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Conflict of interest statement

Conflict-of-interest disclosure: O.L. has received grants from the Leukemia & Lymphoma Society, Rising Tide Foundation, Memorial Sloan Kettering Cancer Center, the National Institutes of Health, the US Food and Drug Administration, the Multiple Myeloma Research Foundation, the International Monetary Fund, Perelman Family Foundation, Amgen, Celgene, Janssen, Takeda, Glenmark, Seattle Genetics, and Karyopharm; has received honoraria for scientific talks and has participated in advisory boards for Adaptive Biotechnologies, Amgen, Binding Site, Bristol Myers Squibb, Celgene, Cellectis, Glenmark, Janssen, Juno, and Pfizer; and has served on independent data monitoring committees for international randomized trials by Takeda, Merck, Janssen, and Theradex. F.M. declares no competing financial interests.

Conflict-of-interest disclosure: O.L. has received grants from the Leukemia & Lymphoma Society, Rising Tide Foundation, Memorial Sloan Kettering Cancer Center, the National Institutes of Health, the US Food and Drug Administration, the Multiple Myeloma Research Foundation, the International Monetary Fund, Perelman Family Foundation, Amgen, Celgene, Janssen, Takeda, Glenmark, Seattle Genetics, and Karyopharm; has received honoraria for scientific talks and has participated in advisory boards for Adaptive Biotechnologies, Amgen, Binding Site, Bristol Myers Squibb, Celgene, Cellectis, Glenmark, Janssen, Juno, and Pfizer; and has served on independent data monitoring committees for international randomized trials by Takeda, Merck, Janssen, and Theradex. F.M. declares no competing financial interests.

Comment on

  • Natural history of monoclonal B-cell lymphocytosis among relatives in CLL families.
    Slager SL, Lanasa MC, Marti GE, Achenbach SJ, Camp NJ, Abbasi F, Kay NE, Vachon CM, Cerhan JR, Johnston JB, Call TG, Rabe KG, Kleinstern G, Boddicker NJ, Norman AD, Parikh SA, Leis JF, Banerji V, Brander DM, Glenn M, Ferrajoli A, Curtin K, Braggio E, Shanafelt TD, McMaster ML, Weinberg JB, Hanson CA, Caporaso NE. Slager SL, et al. Blood. 2021 Apr 15;137(15):2046-2056. doi: 10.1182/blood.2020006322. Blood. 2021. PMID: 33512457 Free PMC article.

References

    1. Slager SL, Lanasa MC, Marti GE, et al. . Natural history of monoclonal B-cell lymphocytosis among relatives in CLL families. Blood. 2021;137(15):2046-2056. - PMC - PubMed
    1. Goldin LR, Landgren O, Marti GE, Caporaso NE. Familial aspects of chronic lymphocytic leukemia, monoclonal B-cell lymphocytosis (MBL), and related lymphomas. Eur J Clin Med Oncol. 2010;2(1):119-126. - PMC - PubMed
    1. Landgren O, Kyle RA, Pfeiffer RM, et al. . Monoclonal gammopathy of undetermined significance (MGUS) consistently precedes multiple myeloma: a prospective study. Blood. 2009;113(22):5412-5417. - PMC - PubMed
    1. Landgren O, Albitar M, Ma W, et al. . B-cell clones as early markers for chronic lymphocytic leukemia. N Engl J Med. 2009;360(7):659-667. - PMC - PubMed
    1. Fazi C, Scarfò L, Pecciarini L, et al. . General population low-count CLL-like MBL persists over time without clinical progression, although carrying the same cytogenetic abnormalities of CLL. Blood. 2011;118(25):6618-6625. - PubMed