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Review
. 2021 Apr 15;11(1):60.
doi: 10.1186/s13613-021-00849-x.

Outcome of acute kidney injury: how to make a difference?

Matthieu Jamme  1   2   3 , Matthieu Legrand  4 , Guillaume Geri  5   6   7
Affiliations
Review

Outcome of acute kidney injury: how to make a difference?

Matthieu Jamme et al. Ann Intensive Care. .

Abstract

Background: Acute kidney injury (AKI) is one of the most frequent organ failure encountered among intensive care unit patients. In addition to the well-known immediate complications (hydroelectrolytic disorders, hypervolemia, drug overdose), the occurrence of long-term complications and/or chronic comorbidities related to AKI has long been underestimated. The aim of this manuscript is to briefly review the short- and long-term consequences of AKI and discuss strategies likely to improve outcome of AKI.

Main body: We reviewed the literature, focusing on the consequences of AKI in all its aspects and the management of AKI. We addressed the importance of clinical management for improving outcomes AKI. Finally, we have also proposed candidate future strategies and management perspectives.

Conclusion: AKI must be considered as a systemic disease. Due to its short- and long-term impact, measures to prevent AKI and limit the consequences of AKI are expected to improve global outcomes of patients suffering from critical illnesses.

Keywords: Acute kidney injury; Chronic kidney disease; Intensive care; Long-term outcome.

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Conflict of interest statement

Dr Jamme reports lectures fees from Alexion. Pr Legrand reports lecture fees from Baxter and Fresenius, consulting fees from Novartis and research support from Sphingotec. Pr Geri reports accomodation fees from BD-Bard.

Figures

Fig. 1
Fig. 1
The three steps of renal management. Green, yellow and red boxes represented interventions with, respectively, surely, possibly and insufficient level of evidence of benefit. AKI, acute kidney injury; mABP, mean arterial blood pressure; RRT, renal replacement therapy; SRAA, renin angiotensin aldosterone system
Fig. 2
Fig. 2
Acute kidney injury bundles of care (derived from the KDIGO AKI management guidelines). Grey boxes indicate action to establish according to KDIGO severity stages. AKI, acute kidney injury; RRT, renal replacement therapy
See this image and copyright information in PMC

References

    1. Smith HW. The kidney: structure and function in health and disease. New York: Oxford University Press; 1951.
    1. Kellum JA, Levin N, Bouman C, Lameire N. Developing a consensus classification system for acute renal failure. Curr Opin Crit Care. 2002;8(6):509–514. doi: 10.1097/00075198-200212000-00005. - DOI - PubMed
    1. Uchino S, Kellum JA, Bellomo R, et al. Acute renal failure in critically ill patients: a multinational, multicenter study. JAMA. 2005;294(7):813–818. doi: 10.1001/jama.294.7.813. - DOI - PubMed
    1. de Mendonça A, Vincent JL, Suter PM, Moreno R, Dearden NM, Antonelli M, et al. Acute renal failure in the ICU: risk factors and outcome evaluated by the SOFA score. Intensive Care Med. 2000;26(7):915–921. doi: 10.1007/s001340051281. - DOI - PubMed
    1. Bellomo R, Ronco C, Kellum JA, Mehta RL, Palevsky P, Acute Dialysis Quality Initiative workgroup Acute renal failure—definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group. Crit Care Lond Engl. 2004;8(4):R204–212. doi: 10.1186/cc2872. - DOI - PMC - PubMed