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Case Reports
. 2021 Jun;39(2):145-151.
doi: 10.3857/roj.2020.01060. Epub 2021 Mar 24.

Intrathyroidal parathyroid carcinoma: a case report and literature review

Kenza Benali  1   2 , Jihan Aarab  1   2 , Houda Benmessaoud  1   2 , Abdelati Nourreddine  1   3 , Sanaa El Majjaoui  1   2 , Hanan El Kacemi  1   2 , Tayeb Kebdani  1   2 , Noureddine Benjaafar  1   2
Affiliations
Case Reports

Intrathyroidal parathyroid carcinoma: a case report and literature review

Kenza Benali et al. Radiat Oncol J. 2021 Jun.

Abstract

Parathyroid carcinoma is an uncommon endocrine malignancy comprising 0.5%-2% of patients with primary hyperparathyroidism. The probability of an intrathyroidal location is low (0.2%) and make preoperative suspicion and diagnosis challenging. Less than 20 cases of intrathyroidal parathyroid carcinoma have been reported. We introduce a case of intrathyroidal parathyroid carcinoma mimicking a suspicious thyroid nodule, and review the literature, with a focus on the role of adjuvant radiotherapy.

Keywords: Adjuvant radiotherapy; Intrathyroidal parathyroid carcinoma; Thyroidectomy; Volumetric-Modulated arc therapy.

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Conflict of interest statement

Conflict of Interest

No potential conflict of interest relevant to this article was reported.

Figures

Fig. 1.
Fig. 1.
Early and delayed 99mTc-methoxy-isobutyl-isonitrile (99mTc-MIBI) scintigraphy showed focal uptake in the right anterior neck, suggestive of residual disease.
Fig. 2.
Fig. 2.
(A) Adjuvant radiation therapy was delivered via volumetric modulated arc therapy to the regions of low- and high-risk, to doses of 56 Gy (green) and 70 Gy (red), respectively. (B) Axial views of the planning computed tomography scan with 66.5 Gy (95%; in yellow), and 53.2 Gy (95%; in blue) isodose lines. (C) Cumulative dose-volume histogram for planning target volume.
Fig. 3.
Fig. 3.
Evolution of serum parathyroid hormone levels (pg/mL) after radiation therapy.
See this image and copyright information in PMC

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