Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2021 Apr 14;29(4):540-542.
doi: 10.1016/j.chom.2021.03.013.

Nature or nurture: Factors that influence bnAb development

Elise Landais  1 , Devin Sok  2
Affiliations
Free article
Comment

Nature or nurture: Factors that influence bnAb development

Elise Landais et al. Cell Host Microbe. .
Free article

Abstract

The stochastic development of broadly neutralizing antibodies (bnAbs) to HIV-1 is influenced by complex viral and host interactions. In this issue of Cell Host & Microbe, Townsley et al. reveal that early B cell and virus interactions during acute infection are predictive for developing bnAb responses later in infection.

PubMed Disclaimer

Comment on

  • B cell engagement with HIV-1 founder virus envelope predicts development of broadly neutralizing antibodies.
    Townsley SM, Donofrio GC, Jian N, Leggat DJ, Dussupt V, Mendez-Rivera L, Eller LA, Cofer L, Choe M, Ehrenberg PK, Geretz A, Gift S, Grande R, Lee A, Peterson C, Piechowiak MB, Slike BM, Tran U, Joyce MG, Georgiev IS, Rolland M, Thomas R, Tovanabutra S, Doria-Rose NA, Polonis VR, Mascola JR, McDermott AB, Michael NL, Robb ML, Krebs SJ. Townsley SM, et al. Cell Host Microbe. 2021 Apr 14;29(4):564-578.e9. doi: 10.1016/j.chom.2021.01.016. Epub 2021 Mar 3. Cell Host Microbe. 2021. PMID: 33662277 Free PMC article.

Substances

LinkOut - more resources