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Review
. 2021 Apr 15;21(1):214.
doi: 10.1186/s12935-021-01906-y.

Emerging cellular and molecular mechanisms underlying anticancer indications of chrysin

Marjan Talebi  1 , Mohsen Talebi  2   3 , Tahereh Farkhondeh  4   5 , Jesus Simal-Gandara  6 , Dalia M Kopustinskiene  7 , Jurga Bernatoniene  7 , Saeed Samarghandian  8
Affiliations
Review

Emerging cellular and molecular mechanisms underlying anticancer indications of chrysin

Marjan Talebi et al. Cancer Cell Int. .

Abstract

Chrysin has been shown to exert several beneficial pharmacological activities. Chrysin has anti-cancer, anti-viral, anti-diabetic, neuroprotective, cardioprotective, hepatoprotective, and renoprotective as well as gastrointestinal, respiratory, reproductive, ocular, and skin protective effects through modulating signaling pathway involved in apoptosis, oxidative stress, and inflammation. In the current review, we discussed the emerging cellular and molecular mechanisms underlying therapeutic indications of chrysin in various cancers. Online databases comprising Scopus, PubMed, Embase, ProQuest, Science Direct, Web of Science, and the search engine Google Scholar were searched for available and eligible research articles. The search was conducted by using MeSH terms and keywords in title, abstract, and keywords. In conclusion, experimental studies indicated that chrysin could ameliorate cancers of the breast, gastrointestinal tract, liver and hepatocytes, bladder, male and female reproductive systems, choroid, respiratory tract, thyroid, skin, eye, brain, blood cells, leukemia, osteoblast, and lymph. However, more studies are needed to enhance the bioavailability of chrysin and evaluate this agent in clinical trial studies.

Keywords: Apoptosis; Cancer; Chrysin; Flavonoids; Inflammation; Metastasis; Oxidative stress; Proliferation; Transcription factors.

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Conflict of interest statement

There is no competing of interests.

Figures

Fig. 1
Fig. 1
Chrysin chemical structure
Fig.2
Fig.2
Association of structural modification of chrysin and its substituent pharmacological effects
Fig. 3
Fig. 3
Important mechanisms involved in the anti-cancer activities of chrysin
See this image and copyright information in PMC

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