Comment on "Circadian rhythms in the absence of the clock gene Bmal1"

Katharine C Abruzzi^#¹, Cédric Gobet^#², Felix Naef^#³, Michael Rosbash^#⁴

Affiliations

¹ Howard Hughes Medical Institute, Brandeis University, Waltham, MA, USA.
² Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.
³ Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland. rosbash@brandeis.edu felix.naef@epfl.ch.
⁴ Howard Hughes Medical Institute, Brandeis University, Waltham, MA, USA. rosbash@brandeis.edu felix.naef@epfl.ch.

^# Contributed equally.

PMID: 33859000
DOI: 10.1126/science.abf0922

Comment

Comment on "Circadian rhythms in the absence of the clock gene Bmal1"

Katharine C Abruzzi et al. Science. 2021.

. 2021 Apr 16;372(6539):eabf0922.

doi: 10.1126/science.abf0922.

Authors

Katharine C Abruzzi^#¹, Cédric Gobet^#², Felix Naef^#³, Michael Rosbash^#⁴

Affiliations

¹ Howard Hughes Medical Institute, Brandeis University, Waltham, MA, USA.
² Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.
³ Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland. rosbash@brandeis.edu felix.naef@epfl.ch.
⁴ Howard Hughes Medical Institute, Brandeis University, Waltham, MA, USA. rosbash@brandeis.edu felix.naef@epfl.ch.

^# Contributed equally.

PMID: 33859000
DOI: 10.1126/science.abf0922

Abstract

Ray et al (Reports, 14 February 2020, p. 800) recently claimed temperature-compensated, free-running mRNA oscillations in Bmal1 ^-/- liver slices and skin fibroblasts. We reanalyzed these data and found far fewer reproducible mRNA oscillations in this genotype. We also note errors and potentially inappropriate analyses.

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Comment in

Response to Comment on "Circadian rhythms in the absence of the clock gene Bmal1".
Ray S, Valekunja UK, Stangherlin A, Howell SA, Snijders AP, Damodaran G, Reddy AB. Ray S, et al. Science. 2021 Apr 16;372(6539):eabf1930. doi: 10.1126/science.abf1930. Science. 2021. PMID: 33859002

Comment on

Circadian rhythms in the absence of the clock gene Bmal1.
Ray S, Valekunja UK, Stangherlin A, Howell SA, Snijders AP, Damodaran G, Reddy AB. Ray S, et al. Science. 2020 Feb 14;367(6479):800-806. doi: 10.1126/science.aaw7365. Science. 2020. PMID: 32054765

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Comment on "Circadian rhythms in the absence of the clock gene Bmal1"

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Comment on "Circadian rhythms in the absence of the clock gene Bmal1"

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