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. 2021 Mar 30:2021:8862299.
doi: 10.1155/2021/8862299. eCollection 2021.

Homocysteine Level and Risk of Hemorrhage in Brain Arteriovenous Malformations

Chaofan Zeng  1   2   3   4 , Fa Lin  1   2   3   4 , Peicong Ge  1   2   3   4 , Dong Zhang  1   2   3   4 , Shuo Wang  1   2   3   4 , Jizong Zhao  1   2   3   4   5
Affiliations

Homocysteine Level and Risk of Hemorrhage in Brain Arteriovenous Malformations

Chaofan Zeng et al. Dis Markers. .

Abstract

Objective: We aimed to investigate the risk factors associated with hemorrhage and clarify the relation of homocysteine (Hcy) with brain arteriovenous malformations (bAVMs).

Method: We retrospectively reviewed bAVM patients from Beijing Tiantan Hospital between January 2019 and December 2019. Clinical and laboratory variables were analyzed in enrolled patients with bAVMs. Potential predictors associated with hemorrhage were evaluated by logistic regression analysis.

Results: A total of 143 bAVM patients were identified in the study, including 69 unruptured and 74 ruptured cases. Patients with hemorrhage were less likely to have hyperhomocysteinemia (P = 0.023). Logistic regression analysis showed that increased maximum diameter of bAVM lesions (odds ratio (OR) 0.634, 95% confidence intervals (CI) 0.479-0.839; P = 0.001) and serum Hcy level (OR 0.956, 95% CI 0.920-0.993; P = 0.021) were associated with lower risk of hemorrhage in bAVMs.

Conclusion: The present study provided evidence regarding the association between serum Hcy and hemorrhage in patients with bAVMs. Higher Hcy level was correlated with a lower risk of rupture. Detection of factors for subsequent hemorrhage is necessary to develop therapeutic strategies for bAVMs preferably.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
Flow diagram of the study participants. bAVMs: brain arteriovenous malformations; DSA: digital subtraction angiography.
Figure 2
Figure 2
Odds ratio for hemorrhage in bAVMs, according to Hcy and HHcy. Model 1: adjusted for age, sex, cigarette smoking, eloquent location, deep venous drainage, maximum diameter of lesions, and Hcy. Model 2: additionally adjusted for prior treatment of embolization, deep location, and associated aneurysm. CI: confidence intervals; Hcy: homocysteine; HHcy: hyperhomocysteinemia.
Figure 3
Figure 3
A linear relationship between Hcy level and probability of hemorrhage in the regression model. Hcy: homocysteine.
See this image and copyright information in PMC

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