Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Mar 12;13(3):e13855.
doi: 10.7759/cureus.13855.

Effect of Serum Ferritin on the Association Between Coffee Intake and Hyperuricemia Among American Women: The National Health and Nutrition Examination Survey

Dayawa D Agoons  1 , Batakeh B Agoons  2 , Arnaud D Kaze  3   4 , Saketram Komanduri  1
Affiliations

Effect of Serum Ferritin on the Association Between Coffee Intake and Hyperuricemia Among American Women: The National Health and Nutrition Examination Survey

Dayawa D Agoons et al. Cureus. .

Abstract

Background Accruing evidence suggests an inverse relationship between coffee intake and serum uric acid. The mechanism(s) explaining this inverse relationship remains elusive. The aim of this study was to assess if the association between coffee intake and hyperuricemia is mediated via serum ferritin in women. Methods We pooled data from the 2003 to 2006 National Health and Nutrition Examination Survey (NHANES). We included women with complete information on all key variables. Coffee intake was classified as none, <1 cup/day, 1-3 cups/day, and ≥4 cups/day. Hyperuricemia was defined as serum uric acid >5.7 mg/dL. We assessed the association between coffee intake and hyperuricemia using logistic regression. Path analysis was used to examine whether serum ferritin mediated the effect of coffee on hyperuricemia. Results Among 2,139 women (mean age: 31.2 years [SD: 9.2]), mean serum uric acid was 4.4 mg/dL (SD: 1.0), and 227 (10.6%) had hyperuricemia. In multivariate logistic regression models, intake of ≥4 cups/day of coffee was associated with lower odds of hyperuricemia (OR 0.28 [95% CI: 0.09, 091], P=0.035). The total direct and indirect effect of coffee on hyperuricemia via serum ferritin was -0.16, P=0.009 and -8.1 × 10- 3, P=0.204, respectively. Conclusion Among women, moderate coffee consumption was inversely related to hyperuricemia by direct effect, rather than indirectly through the effects of serum ferritin. These findings suggest that serum ferritin does not mediate the inverse association between coffee and hyperuricemia in women.

Keywords: arthritis; crystal arthropathies; gout.

PubMed Disclaimer

Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Summary of mediation analysis
Standardized pathway coefficients are shown by category of coffee consumption. Effect sizes are shown adjusted for age, alcohol consumption, smoking, diabetes, hypertension, and eGFR. SE: standard error; HU: hyperuricemia.
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Coffee consumption and risk for type 2 diabetes mellitus. Salazar-Martinez E, Willett WC, Ascherio A, Manson JE, Leitzmann MF, Stampfer MJ, Hu FB. Ann Intern Med. 2004;140:1–8. - PubMed
    1. Lundsberg LS. Caffeine. Boca Raton: CRC Press; 1998. Caffeine consumption; pp. 199–224.
    1. Coffee consumption and risk of incident gout in women: the Nurses’ Health Study. Choi HK, Curhan G. Am J Clin Nutr. 2010;92:922–927. - PMC - PubMed
    1. Coffee, tea, and caffeine consumption and serum uric acid level: the third national health and nutrition examination survey. Choi HK, Curhan G. Arthritis Rheum. 2007;15:816–821. - PubMed
    1. Effects of coffee consumption on serum uric acid: systematic review and meta-analysis. Park KY, Kim HJ, Ahn HS, Kim SH, Park EJ, Yim SY, Jun JB. Semin Arthritis Rheum. 2016;45:580–586. - PubMed

LinkOut - more resources