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. 2021 Mar 4;4(2):1021-1023.
doi: 10.1021/acsptsci.1c00059. eCollection 2021 Apr 9.

COVID-19: Does SARS-CoV-2 Modulate Acanthamoeba Epigenetics to Enhance Survival and Transmission in the Environment?

Jibran Sualeh Muhammad  1 , Ruqaiyyah Siddiqui  2 , Naveed Ahmed Khan  3
Affiliations

COVID-19: Does SARS-CoV-2 Modulate Acanthamoeba Epigenetics to Enhance Survival and Transmission in the Environment?

Jibran Sualeh Muhammad et al. ACS Pharmacol Transl Sci. .

Abstract

For the first time, we propose the role of epigenetic mechanisms in severe acute respiratory syndrome coronavirus-2 survival inside Acanthamoeba and possible transmission via airborne cysts.

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Conflict of interest statement

The authors declare no competing financial interest.

Figures

Figure 1
Figure 1
Mean and relative mRNA expression of HSPA family of genes in COVID-19 patients’ lung autopsies compared to healthy individuals. (A) RNaseq data set GSE150316 obtained from the National Center for Biotechnology Information Gene Expression Omnibus (GEO) (https://www.ncbi.nlm.nih.gov/geo/) was analyzed. This data set contained transcriptomic expression profiles from autopsy samples (Formalin-fixed paraffin-embedded lung tissues) from 5 healthy lungs and 16 lung tissue samples from 5 COVID-19 patients. (B) Mean mRNA expression was calculated and presented as Log2 fold change (Log2FC).
Figure 2
Figure 2
Heat shock protein amino acid sequence alignment and sequence identity of human Hsp70 and Acanthamoeba castellanii high molecular weight HSP. (A) Amino acid sequence alignment, (B) 3D structures, and (C) comparison of the amino acid sequences of human HSP70 (Template) and A. castellanii HSP (Target); structural identity is shown in green. (The following databases were utilized to obtain these results: https://www.uniprot.org/; https://amoebadb.org/amoeba/app/; https://swissmodel.expasy.org/).
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