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. 2021 Mar 19;4(2):1024-1025.
doi: 10.1021/acsptsci.1c00073. eCollection 2021 Apr 9.

COVID-19: Is There a Link between Alcohol Abuse and SARS-CoV-2-Induced Severe Neurological Manifestations?

Jibran Sualeh Muhammad  1 , Ruqaiyyah Siddiqui  2 , Naveed Ahmed Khan  3
Affiliations

COVID-19: Is There a Link between Alcohol Abuse and SARS-CoV-2-Induced Severe Neurological Manifestations?

Jibran Sualeh Muhammad et al. ACS Pharmacol Transl Sci. .

Abstract

For the first time, it is shown that severe COVID-19 associated genes (CCR2, DPP9, HSPA1L, TYK2, OAS1, ACE2, and TMPRSS2) were also upregulated in the brain tissue of chronic alcoholics. It is proposed that chronic alcohol abuse should be considered as an important factor in COVID-19-associated neurological complications.

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Conflict of interest statement

The authors declare no competing financial interest.

Figures

Figure 1
Figure 1
Transcriptomic analysis using publicly available databases from NCBI Gene Expression Omnibus (https://www.ncbi.nlm.nih.gov/geo/). (A) Boxplot showing analysis of GSE150316 data set containing RNaseq data obtained from autopsy samples from severe COVID-19 patients (n = 11) compared to healthy controls (n = 5). (B and C) Bar graphs showing analysis of GSE53808 data set containing expression array data obtained from brain white matter tissues from alcoholics without hepatic encephalopathy (n = 4) and neurologically normal controls (n = 3). Data is presented as mean ± SE in error bars.
See this image and copyright information in PMC

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