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Review
. 2022 Jan;65(1):93-106.
doi: 10.1007/s11427-020-1911-9. Epub 2021 Apr 13.

Constructing the rodent stereotaxic brain atlas: a survey

Zhao Feng  1   2 , Anan Li  1   2 , Hui Gong  3   4 , Qingming Luo  5   6   7
Affiliations
Review

Constructing the rodent stereotaxic brain atlas: a survey

Zhao Feng et al. Sci China Life Sci. 2022 Jan.

Abstract

The stereotaxic brain atlas is a fundamental reference tool commonly used in the field of neuroscience. Here we provide a brief history of brain atlas development and clarify three key conceptual elements of stereotaxic brain atlasing: brain image, atlas, and stereotaxis. We also refine four technical indices for evaluating the construction of atlases: the quality of staining and labeling, the granularity of delineation, spatial resolution, and the precision of spatial location and orientation. Additionally, we discuss state-of-the-art technologies and their trends in the fields of image acquisition, stereotaxic coordinate construction, image processing, anatomical structure recognition, and publishing: the procedures of brain atlas illustration. We believe that the use of single-cell resolution and micron-level location precision will become a future trend in the study of the stereotaxic brain atlas, which will greatly benefit the development of neuroscience.

Keywords: brain atlas; brainsmatics; cytoarchitecture; stereotaxic.

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References

    1. Adler, D.H., Pluta, J., Kadivar, S., Craige, C., Gee, J.C., Avants, B.B., and Yushkevich, P.A. (2014). Histology-derived volumetric annotation of the human hippocampal subfields in postmortem MRI. NeuroImage 84, 505–523. - PubMed
    1. AIBS. (2008). Technical White Paper: Allen Reference Atlas—version 1 (2008). Seattle: Allen Institute for Brain Science.
    1. AIBS. (2011). Technical White Paper: Allen Reference Atlas—version 2 (2011). Seattle: Allen Institute for Brain Science.
    1. AIBS. (2015). Technical White Paper: Allen Mouse Common Coordinate Framework. Seattle: Allen Institute for Brain Science.
    1. Ali, A.A., Dale, A.M., Badea, A., and Johnson, G.A. (2005). Automated segmentation of neuroanatomical structures in multispectral MR microscopy of the mouse brain. NeuroImage 27, 425–435. - PubMed

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