Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021:1308:217-224.
doi: 10.1007/978-3-030-64872-5_15.

Use of Plant-Derived Natural Products in Sleep Disturbances

Diana Lelli  1 , Livio Cortese  2 , Claudio Pedone  2
Affiliations
Review

Use of Plant-Derived Natural Products in Sleep Disturbances

Diana Lelli et al. Adv Exp Med Biol. 2021.

Abstract

Sleep disorders have a high prevalence both in the general population and especially in specific populations such older adults and oncologic patients. Impacting on quality of life, they often translate in drug prescription, with consequent increased risk of drug-drug interactions and adverse drug reactions. In the last years several products derived from plants have been developed with the aim of treating insomnia with lower risk of side effects. Despite several studies have been performed with this aim, the available evidence is inconclusive, and reviews summarizing the most recent evidences on the effectiveness of plant-derived products in treating insomnia are lacking.This narrative review aims at summarizing the evidences of the mechanism of action, effectiveness and safety of the most commonly used plant-derived products for the treatment of sleep disorders (Valerian, Lemon balm, Passionflower, Chamomile, Hops, and Jujube).

Keywords: Chamomile; Hops; Insomnia; Jujube; Lemon balm; Passionflower; Phytotherapy; Valerian.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Ohayon MM (2011) Epidemiological overview of sleep disorders in the general population. Sleep Med Res 2(1):1–9
    1. Katz DA, McHorney CA (1998) Clinical correlates of insomnia in patients with chronic illness. Arch Intern Med 158(10):1099–1107 - PubMed
    1. Dujardin S, Pijpers A, Pevernagie D (2018) Prescription drugs used in insomnia. Sleep Med Clin 13(2):169–182 - PubMed
    1. Romero K, Goparaju B, Russo K, Westover MB, Bianchi MT (2017) Alternative remedies for insomnia: a proposed method for personalized therapeutic trials. Nat Sci Sleep 9:97–108 - PubMed - PMC
    1. Sateia MJ, Buysse DJ, Krystal AD, Neubauer DN, Heald JL (2017) Clinical practice guideline for the pharmacologic treatment of chronic insomnia in adults: an American Academy of Sleep Medicine Clinical Practice Guideline. J Clin Sleep Med 13(2):307–349 - PubMed - PMC

Substances

LinkOut - more resources