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. 2021 Apr 16;16(4):e0249346.
doi: 10.1371/journal.pone.0249346. eCollection 2021.

Clinical characteristics of Egyptian male patients with COVID-19 acute respiratory distress syndrome

Ahmed S Doghish  1   2 , Walid F Elkhatib  3   4 , Essam A Hassan  5 , Ahmed F Elkhateeb  6 , Eman E Mahmoud  7 , Mona I Ahmed  8 , Mahmoud A F Khalil  9
Affiliations

Clinical characteristics of Egyptian male patients with COVID-19 acute respiratory distress syndrome

Ahmed S Doghish et al. PLoS One. .

Erratum in

Abstract

Background: Coronavirus disease 2019 (COVID-19) is a serious illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and in severe cases associated with acute respiratory distress syndrome (ARDS).

Objective: To describe the clinical characteristics of patients with ARDS-COVID-19.

Materials and methods: This study involved 197 male Egyptian participants, among them111 COVID-19 patients presented with ARDS, 60 COVID-19 patients presented with non-ARDS, and 26 Non-COVID-19 patients. We reported the analysis results of clinical and laboratory information, including blood routine tests, blood biochemistry parameters [aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatinine and C-reactive protein (CRP)], thrombotic activity (D-dimer) and serum ferritin and lactate dehydrogenase (LDH).

Results: The levels of hemoglobin, AST, creatinine, monocyte count, monocyte %, RBC count, TLC, and platelet count were not significantly different among the groups. The lymphopenia and increased CRP, ALT, D-dimer, ferritin, and LDH were observed in patients with ARDS-COVID-19.

Conclusion: COVID-19 patients with ARDS presented with lymphopenia, increased thrombotic activity, increased CRP, LDH, and ferritin levels. The results revealed that CRP, D-dimer, LDH levels, and lymphopenia have a significant association with the COVID-19 severity and can be used as biomarkers to predict the disease severity.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1
ROC curve for CRP (A), D.dimer (B), ferritin (C), and LDH (D) levels among investigated groups.
See this image and copyright information in PMC

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