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Comment
. 2021 Apr 15;28(4):433-435.
doi: 10.1016/j.chembiol.2021.03.015.

Chemical control of multidomain acetyltransferase activity

Whitney K Lieberman  1 , Yihang Jing  1 , Jordan L Meier  2
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Free article
Comment

Chemical control of multidomain acetyltransferase activity

Whitney K Lieberman et al. Cell Chem Biol. .
Free article

Abstract

Chromatin-modifying lysine acetyltransferases employ multiple protein domains to regulate transcription. In this issue, Vannam et al. (2021) describe dCBP-1, a small molecule degrader of the multidomain acetyltransferases EP300 and CREBBP. This provides a new tool for interrogating EP300/CREBBP function and also suggests a strategy for pharmacological differentiation of acetyltransferase paralogs.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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