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Comment
. 2021 Apr 15;184(8):1968-1970.
doi: 10.1016/j.cell.2021.03.040.

Neu(ronal) custodians of cutaneous immunity

Kody Paul Mansfield  1 , Shruti Naik  2
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Free article
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Neu(ronal) custodians of cutaneous immunity

Kody Paul Mansfield et al. Cell. .
Free article

Abstract

Sensory neurons have surfaced as key instigators of skin inflammation. In this issue of Cell, Zhang et al. define an anti-inflammatory Langerhans cell (LC)-neuron-mast cell (MC) circuit that underlies skin immune homeostasis. They uncover a role for LCs in maintaining innervation of MrgprD+ nonpeptidergic neurons that restrain MC activation via glutamate secretion.

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